Phytochemistry of compounds isolated from the leaf-surface extract of Psiadia punctulata (DC.) Vatke growing in Saudi Arabia

Phytochemistry
Fabrizio Dal PiazLorella Severino

Abstract

The surface extract of an accession of Psiadia punctulata (DC.) Vatke (Asteraceae) growing in Saudi Arabia was investigated for its phytochemical composition. A bio-guided investigation of the extract led to the isolation of thirteen ent-kaurane and trachylobane diterpenes and seventeen compounds previously described, including nine flavonoids and eight diterpenes. Three flavonoids and one ent-kaurane diterpene showed antimicrobial activity with MIC100 values ranging from 25 to 150 μg/ml. The extract showed antibacterial activity against Staphylococcus aureus (MIC100 = 180 μg/ml) and antifungal activity against Candida albicans (MIC0 = 130 μg/ml). The isolated 3',4',5,7-tetramethoxyflavone, at a concentration of 40 μg/ml, displayed the ability to reduce biofilm formation of S. aureus and C. albicans by 50% and 90% respectively.

Citations

Aug 25, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ziad OmranMajed Halwani
Mar 18, 2020·Journal of Natural Products·Angela BisioNunziatina De Tommasi
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hamdi El-SaidGuido Flamini
Jun 3, 2021·Journal of Fungi·Tomasz M KarpińskiArtur Adamczak
Aug 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Mohammad Zubair Alam, Mohd Sajjad Ahmad Khan
Nov 27, 2019·Journal of the American Chemical Society·Lukas Anton WeinThomas Magauer
Aug 23, 2021·Chinese Journal of Natural Medicines·Fu-Juan SunMing-Hua Yang
Jul 1, 2020·Mini Reviews in Medicinal Chemistry·Hsuan HsuVeronica Veses

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