Phytocosmeceutical formulation development, characterization and its in-vivo investigations

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Imran Shair MohammadHaji Muhammad Shoaib Khan

Abstract

Several plants found rich in flavonoid, polyphenols, and antioxidants reported antiaging, oppose inflammation and carcinogenic properties but have rarely been applied in dermatology. The present study was an active attempt to formulate a stable phytocosmetic emulsion system loaded with 2% pre-concentrated Prosopis cineraria bark extract, aiming to revive facial skin properties. In order to obtain potent therapeutic activities, we first prepared extracts of stem, leaves, and bark and screen them on basis of phenolic, flavonoids contents and antioxidant, antibacterial, lipoxygenase and tyrosinase inhibition activities. Furthermore, cytocompatibility of the extract was also determined prior starting in vivo investigations. Then the in vivo performance of 2% bark extract loaded emulsion formulation was determined by using non-invasive probe cutometer and elastometer with comparison to base formulation. The preliminary experiment showed that bark extract has a significant amount of phenolic and flavonoid compounds with eminent antioxidant potential. Furthermore, indicated an efficient antibacterial, lipoxygenase, and tyrosinase enzyme inhibition activities. Importantly, the bark extract did not induce any toxicity or apoptosis, when...Continue Reading

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Citations

May 23, 2021·Journal of Cosmetic Dermatology·Rabia TasneemPalwasha Khan
Sep 4, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Laurence Imhof, Deborah Leuthard

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