PMID: 6980394May 1, 1982Paper

Phytohaemagglutinin reactivity in circulating peripheral blood lymphocytes during a Trypanosoma brucei infection: sequential studies in individual guinea-pigs

Parasite Immunology
J A Longstaffe, R J Terry

Abstract

This study has analysed the response to phytohaemagglutinin of peripheral blood lymphocytes from guinea-pigs infected with Trypanosoma brucei brucei. By this means it was possible to follow the response of individual animals throughout an infection. A culture method using whole blood permitted fewer cell manipulations and eliminated the necessity to supplement cultures with heterologous serum. Selection of appropriate strains of T.b. brucei produced a relatively chronic infection in guinea-pigs. Results from this system indicate that, even late in the disease, significant mitogen reactivity still remains in some individuals. More significantly, these mitogen 'responders' controlled successive parasitaemic waves producing a fluctuating parasitaemia whereas the animals showing poor mitogen responsiveness--'non-responders' failed to control successive waves and showed plateau parasitaemias.

References

Jul 1, 1978·The American Journal of Tropical Medicine and Hygiene·D W Taylor, W A Siddiqui
Jul 1, 1977·Tissue Antigens·D Franks, B A Bradley
Feb 10, 1977·Nature·A N Jayawardena, B H Waksman
May 1, 1977·Journal of the Experimental Analysis of Behavior·D G Ramer, D M Wilkie
Aug 1, 1978·Cellular Immunology·J M Mansfield
Mar 1, 1979·Diseases of the Colon and Rectum·J C Bonello, J S Abrams
May 1, 1977·Infection and Immunity·R G RankW P Weidanz
Dec 1, 1976·Experimental Parasitology·W J Herbert, W H Lumsden
Oct 1, 1976·Experimental and Molecular Pathology·A ButkusK G McCullagh
Jan 22, 1972·Lancet·B M GreenwoodA Palit
Jan 1, 1973·Transactions of the Royal Society of Tropical Medicine and Hygiene·P K MurrayF W Jennings
Jan 1, 1973·Transactions of the Royal Society of Tropical Medicine and Hygiene·G M UrquhartE Bate
Jan 1, 1973·Transactions of the Royal Society of Tropical Medicine and Hygiene·B M GreenwoodD H Molyneux
Aug 1, 1974·Infection and Immunity·J M Mansfield, J H Wallace
Jan 1, 1967·Transactions of the Royal Society of Tropical Medicine and Hygiene·D G Godfrey, R Killick-Kendrick
Jan 1, 1980·Transactions of the Royal Society of Tropical Medicine and Hygiene·G M Urquhart

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.