Phytohemagglutinin-conditioned medium modulates adherence properties and morphology of hairy cells

Leukemia Research
C MecucciH van den Berghe

Abstract

The effect of a PHA-conditioned medium was tested on a population highly enriched in hairy cells obtained from spleens of patients with hairy cell leukemia. Under PHA-CM treatment hairy cells adhered to both plastic and glass and spread assuming a typical stellate shape, without changing their enzymatic and antigenic properties. Provided PHA-CM was present, stellate adherent hairy cells remained viable in culture for several months. Mononuclear splenic cells from patients with various hematological disorders never showed similar phenotypic modifications after PHA-CM treatment.

References

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