Phytol-derived novel isoprenoid immunostimulants.

Frontiers in Immunology
Roshni Roy Chowdhury, Swapan K Ghosh

Abstract

This review describes the adjuvanticity of novel diterpenoids (synthetic phytol derivatives) compared to some commercially available adjuvants. The efficacy of the phytol-derived immunostimulants was evaluated in terms of their ability to activate innate immunity, amplify various antigen-specific immune responses, and engender immunological memory with no discernible adverse effects in both competent and immune-deficient mice. The profile that emerges out of these studies reveals that the phytol derivatives are excellent immunostimulants, superior to a number of commercial adjuvants in terms of long-term memory induction and activation of both innate and acquired immunity. Additionally, the phytol-derived compounds have no cumulative inflammatory or toxic effects even in immuno-compromised mice.

Citations

Jan 7, 2014·PLoS Neglected Tropical Diseases·Josué de MoraesPedro L S Pinto
Jan 9, 2013·Expert Opinion on Drug Delivery·Swapan K Ghosh, Roshni Roy Chowdhury
Jan 14, 2016·Bioscience, Biotechnology, and Biochemistry·Hsin-Jung HoMichio Komai
Jan 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Peter Mubanga CheukaKelly Chibale
Jan 6, 2018·Bioscience, Biotechnology, and Biochemistry·Hsin-Jung HoMichio Komai
Jun 30, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chinnadurai VeeramaniKhalid S Al-Numair

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BETA
chemical

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