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Phytol loaded PLGA nanoparticles regulate the expression of Alzheimer's related genes and neuronal apoptosis against amyloid-β induced toxicity in Neuro-2a cells and transgenic Caenorhabditis elegans

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association

Nov 14, 2019

Sethuraman SathyaKasi Pandima Devi

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Abstract

Amyloid β (Aβ) induced neurotoxicity has been postulated to initiate synaptic loss and subsequent neuronal degeneration in Alzheimer's disease (AD). The nanoparticles based drug carrier system is considered as a promising therapeutic strategy to combat this incurable disease. It was als...read more

Mentioned in this Paper

Alzheimer's Disease
Azacitidine
Cell Death
Chemotaxis
Down-Regulation
Drug Carriers
Genes
Heat shock proteins
Nerve Degeneration
Phytol
3
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Phytol loaded PLGA nanoparticles regulate the expression of Alzheimer's related genes and neuronal apoptosis against amyloid-β induced toxicity in Neuro-2a cells and transgenic Caenorhabditis elegans

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association

Nov 14, 2019

Sethuraman SathyaKasi Pandima Devi

PMID: 31734340

DOI: 10.1016/j.fct.2019.110962

Abstract

Amyloid β (Aβ) induced neurotoxicity has been postulated to initiate synaptic loss and subsequent neuronal degeneration in Alzheimer's disease (AD). The nanoparticles based drug carrier system is considered as a promising therapeutic strategy to combat this incurable disease. It was als...read more

Mentioned in this Paper

Alzheimer's Disease
Azacitidine
Cell Death
Chemotaxis
Down-Regulation
3

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