Phytopharmacology and Clinical Updates of Berberis Species Against Diabetes and Other Metabolic Diseases

Frontiers in Pharmacology
Tarun BelwalJavier Echeverría

Abstract

The incidences of diabetic mellitus and other metabolic diseases such as hypertension and hyperlipidemia are increasing worldwide; however, the current treatment is not able to control the rapidly increasing trend in diabetes mortality and morbidity. Studies related to the effectiveness of extracts and pure compounds obtained from plants have shown promising responses in preclinical and clinical studies related to these metabolic diseases. Plants belonging to the genus Berberis (Family: Berberidaceae) are widely distributed with nearly 550 species worldwide. Extracts and compounds obtained from Berberis species, especially Berberine alkaloid, showed effectiveness in the management of diabetes and other metabolic diseases. Various pharmacological experiments have been performed to evaluate the effects of Berberis extracts, berberine, and its natural and chemically synthesized derivatives against various cell and animal disease models with promising results. Various clinical trials conducted so far also showed preventive effects of Berberis extracts and berberine against metabolic diseases. The present review focuses on i) research updates on traditional uses, ii) phytopharmacology and clinical studies on Berberis species, and ii...Continue Reading

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Citations

Apr 1, 2020·Frontiers in Pharmacology·Seyed Vahid JasemiJavier Echeverría
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ruth E BarrientosJavier Echeverría
Aug 11, 2020·Frontiers in Pharmacology·Ce TangGang Fan
Oct 8, 2020·Natural Product Research·Andy Wai Kan YeungAtanas G Atanasov
Feb 2, 2021·Frontiers in Molecular Biosciences·Muhammad Javed IqbalJavad Sharifi-Rad
Jul 18, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hammad UllahMaria Daglia
Aug 31, 2021·Expert Opinion on Therapeutic Patents·Yuan KongDong-Dong Li
Nov 9, 2021·Frontiers in Pharmacology·Li-Shan YanYi Zhang

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