Phytosomal nanocarriers as platforms for improved delivery of natural antioxidant and photoprotective compounds in propolis: An approach for enhanced both dissolution behaviour in biorelevant media and skin retention profiles

Journal of Photochemistry and Photobiology. B, Biology
Andi Dian PermanaLatifah Rahman

Abstract

Propolis has been reported to possess rich content of antioxidant compounds and may provide health benefits through oxidative stress reduction. Presently, the formulation activities used to enhance the drug delivery have been hampered due to inherently low aqueous solubility and poor transdermal permeation of the bioactive phenols and flavonoids. Here, we show, the formulation of propolis extract (PE) into phytosome delivery systems. The optimum antioxidant activity was attained through extraction process using 75% v/v ethanol. The phytosome was prepared using thin-layer hydration technique with l-α-Phosphatidylcholine as a phospholipid. Fourier transform infrared (FTIR) was used to investigate the occurrence of molecular interactions between formulation components. This innovative approach could encapsulate >40% of bioactive compounds in PE, namely caffeic acid, quercetin, and kaempferol. FTIR spectroscopy indicated new hydrogen bond formation, supporting successful phytosome formulation. The phytosomes enhanced the dissolution up to 4-folds of bioactive compounds in bio-mimicked release media, as well as improved penetrability and skin retention up to 6-folds of the three main compounds of propolis, when compared to non-encap...Continue Reading

Citations

Aug 13, 2020·Pharmaceutics·Supandeep Singh HallanElisabetta Esposito
Aug 21, 2020·Drug Delivery and Translational Research·Heba M K EbadaOssama Y Abdallah
Jul 31, 2021·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Ravindra PandeyBina Gidwani
Nov 4, 2021·Journal of Liposome Research·Manish Kumar GuptaPrashant Gurav

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