Phytosphingosine-1-phosphate represses the hydrogen peroxide-induced activation of c-Jun N-terminal kinase in human dermal fibroblasts through the phosphatidylinositol 3-kinase/Akt pathway

Archives of Dermatological Research
Jeong Pyo LeeSungkwan An

Abstract

Dermal fibroblasts are differentiated mesenchymal cells that regulate the extracellular matrix through the production of dermis components. Dermal fibroblasts can be damaged by reactive oxygen species induced by ultraviolet rays and chemicals. In addition to its effects on the dermis, oxidative stress poses a major threat to organisms and is believed to play an essential role in many disease processes. In this study, we show that human dermal fibroblasts (HDFs) express sphingosine-1-phosphate (S1P) receptors S1P(1), S1P(2), and S1P(3). In addition, cell viability of HDFs is increased by phytosphingosine-1-phosphate (PhS1P) via regulation of the Jun N-terminal kinase (JNK)/Akt pathway. Interestingly, regulation of the JNK/Akt pathway by PhS1P attenuated H(2)O(2)-induced cell growth arrest. Together, our data indicate that PhS1P attenuates H(2)O(2)-induced growth arrest through regulation of the signal molecules Akt and JNK, and suggest that PhS1P may have value as an anti-aging material in cosmetics and medicine.

References

Oct 1, 1992·The Journal of Investigative Dermatology·M J PetersenS Craig
Aug 1, 1989·The Journal of Investigative Dermatology·L H KligmanN A Kefalides
Jul 21, 1998·Annals of the New York Academy of Sciences·S SpiegelF Wang
Apr 15, 2000·The Journal of Biological Chemistry·N ChungL M Obeid
Jan 12, 2001·Molecular and Cellular Biology·A H KimM V Chao
Sep 5, 2001·Nature Cell Biology·J G TomaF D Miller
Dec 1, 2001·Science·T HlaM J Kluk
May 16, 2002·The Journal of Biological Chemistry·Sarah Spiegel, Sheldon Milstien
Jun 19, 2002·Biochimica Et Biophysica Acta·Michael J Kluk, Timothy Hla
Sep 25, 2002·Biochemical and Biophysical Research Communications·Mari Rios CandeloreSuzanne M Mandala
Jan 18, 2003·Biochimica Et Biophysica Acta·Olivier Cuvillier
Apr 3, 2004·Circulation Research·Julie D Saba, Timothy Hla
Sep 21, 2004·Biochemistry. Biokhimii︠a︡·S Vlahopoulos, V C Zoumpourlis
Dec 31, 2005·Molecular Biology of the Cell·Karsten D MeierHoward Riezman
May 6, 2006·Biochemical and Biophysical Research Communications·Mi-Kyoung KimYoe-Sik Bae
Aug 29, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Marie A Bogoyevitch
Sep 26, 2006·Biochimica Et Biophysica Acta·Nitai C HaitSarah Spiegel
Dec 13, 2006·Biochimica Et Biophysica Acta·Tarek A TahaLina M Obeid
Mar 27, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lauren CriglerVictoria M Virador
Dec 24, 2009·The New Phytologist·Mickael O PataCarl K-Y Ng
Mar 5, 2011·Microbiology and Molecular Biology Reviews : MMBR·Marie Cargnello, Philippe P Roux
May 4, 2011·World Journal of Biological Chemistry·Yoh TakuwaKazuaki Yoshioka

❮ Previous
Next ❯

Citations

Jan 17, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rasoul GhasemiAbolhassan Ahmadiani
Jan 9, 2014·International Journal of Molecular Medicine·Hwa Jun ChaSungkwan An
Dec 29, 2020·Cellular Signalling·Brenda Wan Shing LamDeron R Herr

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Related Papers

Biochemical and Biophysical Research Communications
Mi-Kyoung KimYoe-Sik Bae
The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Kenji MatsumotoYoshinori Nozawa
© 2021 Meta ULC. All rights reserved