Phytosterol-mediated inhibition of intestinal cholesterol absorption is independent of ATP-binding cassette transporter A1

The British Journal of Nutrition
Laura Calpe-BerdielFrancisco Blanco-Vaca

Abstract

An increased activity of ATP-binding cassette transporter (ABC) A1 has been proposed as a mechanism underlying the hypocholesterolaemic effect of phytosterols. In the present study, ABCA1-deficient mice (ABCA1-/- mice) were used to examine the involvement of the ABCA1 in the reduction of intestinal cholesterol absorption in response to a phytosterol-enriched diet. A decrease in intestinal cholesterol absorption of 39 and 35 % was observed after phytosterol treatment in ABCA1+/+ mice and in ABCA1-/- mice, respectively. No statistically significant changes in plasma lipoprotein profile or in intestinal ABCG5, ABCG8 and Niemann-Pick C1-Like 1 gene expression levels were found when phytosterol-treated ABCA1-/- mice and untreated ABCA1-/- mice were compared. We conclude that phytosterol inhibition of cholesterol absorption in mice is independent of ABCA1.

References

Apr 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·J McNeishO L Francone
Jul 10, 2002·The Journal of Biological Chemistry·Torsten PlōschFolkert Kuipers
Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jogchum Plat, Ronald P Mensink
Aug 15, 2002·Biochemical and Biophysical Research Communications·Tohru OhamaYuji Matsuzawa
Jan 25, 2003·Current Opinion in Lipidology·Margaret E Brousseau
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Charles JoyceSilvia Santamarina-Fojo
Jul 9, 2003·The Journal of Biological Chemistry·Emi KanekoMakoto Makishima
Aug 14, 2003·The Journal of Nutritional Biochemistry·Ariënne de JongRonald P Mensink
Feb 21, 2004·Science·Scott W AltmannMichael P Graziano
Jan 27, 2005·The Journal of Biological Chemistry·Joanna P DaviesYiannis A Ioannou
Mar 2, 2005·Pharmacology & Therapeutics·Thomas SudhopKlaus von Bergmann
May 4, 2005·The Journal of Nutritional Biochemistry·K C HayesMichael Beer
Jun 9, 2005·Atherosclerosis·Laura Calpe-BerdielFrancisco Blanco-Vaca
Sep 10, 2005·Journal of Lipid Research·Jogchum PlatRonald P Mensink
Sep 10, 2005·Journal of Lipid Research·Ryan E TemelLawrence L Rudel

❮ Previous
Next ❯

Citations

Apr 18, 2012·Canadian Journal of Physiology and Pharmacology·Todd C RideoutDylan S Mackay
Aug 19, 2015·The Science of the Total Environment·Antonio Miranda-FuentesJesús A Gil-Ribes
Jun 23, 2012·Molecular and Cellular Endocrinology·Mariëtte Y M van der WulpAlbert K Groen
Mar 17, 2010·Pharmacology & Therapeutics·Philippe Costet
May 7, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·L Cruz-GarciaD R Tocher
Feb 6, 2008·Metabolism: Clinical and Experimental·Amira N KassisPeter J H Jones
Jan 16, 2007·Atherosclerosis·Laura Calpe-BerdielFrancisco Blanco-Vaca
Apr 24, 2013·Progress in Lipid Research·Miriam Lee-RueckertJoan Carles Escola-Gil
Aug 12, 2008·Atherosclerosis·Laura Calpe-BerdielFrancisco Blanco-Vaca
Jun 24, 2014·Journal of the American College of Nutrition·Nobuko HonguMaciej S Buchowski
Mar 16, 2017·Molecular Nutrition & Food Research·Lídia CedóJoan Carles Escolà-Gil
May 30, 2008·Journal of Lipid Research·Laura Calpe-BerdielJoan Carles Escolà-Gil
Aug 24, 2019·Current Medicinal Chemistry·Lídia CedóJoan Carles Escolà-Gil
Nov 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aneta KopećDavid D Kitts

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.