Phytosterols and atherosclerosis

La Revue de médecine interne
B HanselEric Bruckert

Abstract

Phytosterols/stanols (PS) enriched food products have been shown to consistently lower plasma cholesterol levels. The intake of 2g/d of PS decreases LDL-cholesterol by about 10%. With respect to the association of LDL-cholesterol lowering with reduction in the cardiovascular (CV) risk, it is likely that supplementation in PS reduces the incidence of CV disease. In addition, the vast majority of animal studies have shown that oral administration of PS reduces the progression atherosclerosis. However, it has been recently suggested that an increase in PS plasma concentrations may increase CV risk. Evidence to support this hypothesis come mainly from observations in sitosterolemic patients who hyperabsorb PS and cholesterol and display very high levels of PS, which may be associated with a premature atherosclerosis. Some epidemiological studies in non-sitosterolemic subjects have shown a positive correlation between PS plasma levels and coronary heart disease. However, these are observational studies and some of them present major methodological bias. In addition, recent studies with a larger number of subjects have indicated, either an absence or a negative relationship between PS and the incidence of CV disease. The guidelines o...Continue Reading

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Citations

Jul 5, 2012·Molecular Nutrition & Food Research·José M Lou-BonafonteJesús Osada
Feb 11, 2015·Journal of Dietary Supplements·Todd C RideoutScott V Harding
Jul 25, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Othmane MerahPatrick Vincourt
Nov 8, 2018·Nutrients·Rosa CasasEmilio Sacanella
Dec 12, 2019·Critical Reviews in Food Science and Nutrition·Raquel MateosLaura Bravo

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