Phytosterols and Triterpenoids for Prevention and Treatment of Metabolic-related Liver Diseases and Hepatocellular Carcinoma

Current Pharmaceutical Biotechnology
Isabel Sánchez-CrisóstomoRosa A Bobadilla-Lugo

Abstract

Liver ailments are among the leading causes of death; they originate from viral infections, chronic alcoholism, and autoimmune illnesses, which may chronically be precursors of cirrhosis; furthermore, metabolic syndrome may worsen those hepatopathies or cause Non-alcoholic Fatty Liver Disease (NAFLD) that may advance to non-alcoholic steatohepatitis (NASH). Cirrhosis is the late-stage liver disease and can proceed to hepatocellular carcinoma (HCC). Pharmacological treatment options for liver diseases, cirrhosis, and HCC, are limited, expensive, and not wholly effective. The use of medicinal herbs and functional foods is growing around the world as natural resources of bioactive compounds that would set the basis for the development of new drugs. Plant and food-derived sterols and triterpenoids (TTP) possess antioxidant, metabolic-regulating, immunomodulatory, and anti-inflammatory activities, as well as they are recognized as anticancer agents, suggesting their application strongly as an alternative therapy in some chronic diseases. Thus, it is interesting to review current reports about them as hepatoprotective agents, but also because they structurally resemble cholesterol, sexual hormones, corticosteroids and bile acids due ...Continue Reading

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Citations

Jan 6, 2021·Critical Reviews in Food Science and Nutrition·Fan JieBaiyi Lu
Sep 27, 2019·Food Research International·Lívia Beatriz Aparecida Ribeiro SilvaThomas Prates Ong
Aug 5, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yoo Jung ParkHyung Sik Kim
Dec 7, 2021·Critical Reviews in Food Science and Nutrition·Jing-Wen Yang, Hong-Fang Ji

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