PMID: 18728390DOI: 10.4161/cc.7.17.6514Aug 30, 2008Paper
PI3-K and GSK-3: Akt-ing together with microtubules.
Cell Cycle
Graham J Buttrick, James G Wakefield
Abstract
Phosphoinositide-3-Kinase (PI3-K) and the downstream kinases Akt and Glycogen Synthase Kinase-3 (GSK-3) have recently been implicated in regulating both microtubule (MT) dynamics and organization. Here we review the role of this signalling pathway in controlling MTs, and explore ways in which the kinases and their substrates may co-operate to spatially regulate MTs in different contexts.
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