PI3K and ERK 1-2 regulate early stages during head regeneration in hydra

Development, Growth & Differentiation
Gema C ManuelH R Bode

Abstract

Different signaling systems coordinate and regulate the development of a multicellular organism. In hydra, the canonical Wnt pathway and the signal transduction pathways mediated by PKC and Src regulate early stages of head formation. In this paper, we present evidence for the participation of a third pathway, the PI3K-PKB pathway, involved in this process. The data presented here are consistent with the participation of ERK 1-2 as a point of convergence for the transduction pathways mediated by PKC, Src and PI3K for the regulation of the regeneration of the head in hydra. The specific developmental point regulated by them appears to be the commitment of tissue at the apical end of the regenerate to form the head organizer.

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Citations

Jul 27, 2012·Development Genes and Evolution·Brigitte Galliot
Nov 29, 2007·Development, Growth & Differentiation·Yuki NakataniAkira Kudo
Aug 26, 2014·Developmental Biology·Christian HasseMonika Hassel
May 24, 2014·Zoology : Analysis of Complex Systems, ZACS·Kiyokazu AgataYoshihiko Umesono
Dec 1, 2018·PLoS Genetics·Elizabeth Medina-CastellanosAlfredo Herrera-Estrella
Jul 13, 2006·Differentiation; Research in Biological Diversity·Fernando ArvizuLuis M Salgado
Aug 24, 2021·Frontiers in Cell and Developmental Biology·Hanxue ZhengYuan Yu
Jul 22, 2021·Annual Review of Cell and Developmental Biology·Mansi Srivastava

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