PI3K Inhibitors and Adverse Events: Optimizing Patient Care for the Treatment of Advanced Breast Cancer.

Clinical Journal of Oncology Nursing
Sarah Donahue, Gretchen Santos Fulgencio

Abstract

Excessive activation of the PI3K pathway has been associated with malignant transformation and resistance to treatment in various cancer types. Various PI3K inhibitors have been evaluated in phase 3 clinical trials; however, most have been associated with modest clinical improvement and poor tolerability. The safety profile of PI3K inhibitors poses new challenges in treatment monitoring and management of common adverse events (AEs). The purpose of this article is to provide an overview of AEs associated with PI3K inhibitors, with a focus on alpelisib, as well as guidance on the prevention and management of AEs. The literature and results from phase 3 trials evaluating the efficacy and safety of endocrine therapy plus PI3K inhibitors in patients with advanced breast cancer were reviewed. AEs associated with PI3K inhibitors include hyperglycemia, diarrhea, nausea, rash, and decreased appetite. Prevention strategies are recommended to avoid the development or decrease the severity of these AEs. Patient education and multidisciplinary care are necessary for the optimal care of these patients.

References

Jan 2, 2004·Seminars in Oncology Nursing·Jean Stern, Cindy Ippoliti
Feb 2, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·B DrenoS Seité
Jul 25, 2013·International Journal of Dermatology·Jonathan L CurryVictor G Prieto
Dec 3, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Eleni-Marina KalogirouAlexandra Sklavounou
Apr 4, 2015·Clinical Journal of Oncology Nursing·Ashley Leak BryantBrett Phillips
Aug 4, 2015·Advanced Pharmaceutical Bulletin·Hamed HamishehkarMaryam Kouhsoltani
Feb 13, 2017·The Nursing Clinics of North America·Margaret Barton-BurkeSean Burke
Mar 21, 2017·Clinical Journal of Oncology Nursing·Mikel Ross, Erica Fischer-Cartlidge
Apr 1, 2017·Current Cancer Drug Targets·Sarah L SammonsKimberly L Blackwell
May 7, 2016·Clinical Colorectal Cancer·Matti AaproAntonio Vigano
Jan 19, 2018·Journal of Cellular Biochemistry·Navid SobhaniDaniele Generali
Apr 12, 2018·JAMA Dermatology·Azael Freites-MartinezMario E Lacouture
Jul 23, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F CardosoE P Winer
Oct 31, 2018·American Journal of Clinical Dermatology·Mario Lacouture, Vincent Sibaud
Feb 2, 2019·Clinical Diabetes : a Publication of the American Diabetes Association·UNKNOWN American Diabetes Association
May 16, 2019·The New England Journal of Medicine·Fabrice AndréUNKNOWN SOLAR-1 Study Group
Jul 10, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ashley Odai-AfoteyTara Sanft

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