PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis.

Cell Metabolism
Yong XuJoel K Elmquist

Abstract

Phosphatidyl inositol 3-kinase (PI3K) signaling in the hypothalamus has been implicated in the regulation of energy homeostasis, but the critical brain sites where this intracellular signal integrates various metabolic cues to regulate food intake and energy expenditure are unknown. Here, we show that mice with reduced PI3K activity in the ventromedial hypothalamic nucleus (VMH) are more sensitive to high-fat diet-induced obesity due to reduced energy expenditure. In addition, inhibition of PI3K in the VMH impaired the ability to alter energy expenditure in response to acute high-fat diet feeding and food deprivation. Furthermore, the acute anorexigenic effects induced by exogenous leptin were blunted in the mutant mice. Collectively, our results indicate that PI3K activity in VMH neurons plays a physiologically relevant role in the regulation of energy expenditure.

References

Apr 1, 1988·Brain Research Bulletin·T SakaguchiG Eddlestone
Jun 1, 1987·Proceedings of the Society for Experimental Biology and Medicine·J G Vander TuigD R Romsos
Feb 1, 1983·Journal of the Autonomic Nervous System·H R BerthoudB Jeanrenaud
Jun 1, 1984·Metabolism: Clinical and Experimental·J OkuJ S Fisler
Jul 6, 2000·The Journal of Comparative Neurology·T L DellovadeS A Tobet
Jun 21, 2001·Genesis : the Journal of Genetics and Development·L ZhaoK L Parker
Oct 26, 2001·Nature·K D NiswenderM W Schwartz
Jun 1, 2002·Science·Lewis C Cantley
Aug 6, 2002·Science·Abdul G Dulloo
Jun 6, 2003·The Journal of Biological Chemistry·Bradford B Lowell, Eric S Bachman
Oct 1, 2003·Circulation·Muredach P Reilly, Daniel J Rader
Aug 18, 2004·The International Journal of Biochemistry & Cell Biology·Henrike SellDenis Richard
May 4, 2005·The Journal of Nutrition·Tamara R CastañedaMatthias H Tschöp
Oct 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jean J ZhaoThomas M Roberts
Feb 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sergei MusatovSonoko Ogawa
May 23, 2007·Nature Neuroscience·Akira Yoshii, Martha Constantine-Paton
Jul 10, 2007·Cell Metabolism·Patrick SealeBruce M Spiegelman
Dec 19, 2007·The Journal of Comparative Neurology·Anna MalyalaOline K Rønnekleiv
Dec 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thaddeus J UngerMaribel Rios
May 27, 2008·Physiology & Behavior·Scott A RobertsonMartin G Myers
Jun 3, 2008·Nature Medicine·Christoph BuettnerChristoph Buettner
Dec 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Makoto FukudaJoel K Elmquist

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Citations

Jun 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ki Woo KimJoel K Elmquist
Feb 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lina Sabra-MakkePascale Bossard
Mar 21, 2012·Molecular and Cellular Biology·Zhao HeGen-Sheng Feng
Jun 2, 2012·The Journal of Clinical Investigation·Ki Woo KimJoel K Elmquist
Aug 2, 2014·The Journal of Clinical Investigation·Franck ChiappiniBarbara B Kahn
Aug 27, 2014·The Journal of Clinical Investigation·Xuehong CaoYong Xu
Jul 11, 2014·Journal of Chemical Neuroanatomy·M M H van SwietenG van der Plasse
Feb 26, 2016·Molecular Metabolism·Alexandre CaronMathieu Laplante
Feb 4, 2014·Neuroscience·R Orozco-Solis, P Sassone-Corsi
Aug 9, 2011·Metabolism: Clinical and Experimental·Min Jung ParkGregory G Freund
Nov 19, 2015·Frontiers in Systems Neuroscience·Sebastien M LabbéDenis Richard
May 27, 2015·The Journal of Comparative Neurology·Nina VujovicClifford B Saper
Oct 7, 2015·Frontiers in Endocrinology·Xiaoyong Yang, Hai-Bin Ruan
Jun 23, 2015·The Journal of Clinical Investigation·Pingwen XuYong Xu
Nov 8, 2013·Molecular Metabolism·Shannon M Harlan, Kamal Rahmouni
Nov 30, 2010·Molecular and Cellular Endocrinology·Ki Woo KimJoel K Elmquist
Sep 13, 2011·Cell Metabolism·Giorgio RamadoriRoberto Coppari
May 9, 2012·Cell Metabolism·Jessica T Y Yue, Tony K T Lam
Jun 9, 2016·Current Biology : CB·Johan Ruud, Jens C Brüning
Sep 23, 2016·Molecular Metabolism·Jong-Woo SohnJoel K Elmquist
Oct 22, 2016·Annals of the New York Academy of Sciences·Alexandre Caron, Denis Richard
Nov 19, 2010·Arquivos brasileiros de endocrinologia e metabologia·Jose DonatoCarol Fuzeti Elias
Apr 11, 2018·Frontiers in Endocrinology·Daniella BuonfiglioJosé Cipolla-Neto
Jan 9, 2019·Journal of Neuroendocrinology·David Garcia-GalianoCarol F Elias

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