PMID: 6194477Aug 1, 1983

Pia arachnoid contains substance P originating from trigeminal neurons

Neuroscience
L Y Liu-ChenM A Moskowitz

Abstract

Immunoreactive substance P is present in measurable amounts in pia arachnoid from rat, cat, dog and calf. Levels of substance P in this tissue are comparable to those found in peripheral structures receiving innervation from dorsal root or trigeminal ganglia. Separation and measurement of bovine pia-arachnoid extract by reverse phase high performance liquid chromatography and radioimmunoassay reveals a single peak of activity with a retention time identical to that of substance P. Unilateral lesions of the trigeminal ganglia decrease substance P levels within cat pia arachnoid and accompanying blood vessels ipsilaterally by greater than 50%. These data indicate that most of the substance P surrounding pial blood vessels resides within afferent nerve fibres from trigeminal ganglion cells.

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Related Concepts

Structure of Calf of Leg
Posterior Root of Spinal Nerve
Pia Mater
Muscle Innervation, Function
Blood Vessel
Neurons
Cattle calf (organism)
Bos taurus
Arachnoid Mater
Set of Afferent Nerve Fibers

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