PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis

FEBS Letters
Jun ZhangHong-Bing Shu

Abstract

The TIR domain-containing adapter protein TRIP is critically involved in TLR3-induced IFN-beta production through activation of NF-kappaB and ISRE. In addition, TRIF also induces apoptosis when overexpressed in 293 cells. In this report, we demonstrate that PIASy, a member of the PIAS SUMO-ligase family, interacts with TRIP, IRF-3 and IRF-7. In reporter gene assays, PIASy dramatically inhibits TRIF-induced NF-kappaB, ISRE and IFN-beta activation but not TRIF-induced apoptosis. Furthermore, PIASy also inhibits IRF-3, IRF-7 and Sendai virus-induced ISRE activation. Our results suggest that PIASy is an inhibitor of TRIF-induced ISRE and NF-kappaB activation but not apoptosis.

References

Dec 31, 1997·Science·C D ChungK Shuai
Jun 20, 1998·The Journal of Biological Chemistry·K BurnsJ Tschopp
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·B LiuK Shuai
Jan 28, 1999·The Journal of Biological Chemistry·A M MoilanenJ J Palvimo
Jun 29, 1999·Cold Spring Harbor Symposia on Quantitative Biology·T ManiatisM G Wathelet
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·B LiuK Shuai
Jun 5, 2001·Apoptosis : an International Journal on Programmed Cell Death·V NelsonS A Maxwell
Aug 30, 2001·Nature Immunology·T HorngR Medzhitov
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Marc J ServantRongtuan Lin
Feb 28, 2002·Annual Review of Immunology·Charles A Janeway, Ruslan Medzhitov
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masahiro YamamotoShizuo Akira
Apr 15, 2003·Nature Immunology·Katherine A FitzgeraldTom Maniatis
May 2, 2003·The Journal of Biological Chemistry·Liang-Hua BinHong-Bing Shu
Aug 6, 2003·Current Opinion in Immunology·Elizabeth Kopp, Ruslan Medzhitov
Aug 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jianyin LongFang Liu
Oct 1, 2003·The Journal of Experimental Medicine·Katherine A FitzgeraldDouglas T Golenbock

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Citations

Aug 2, 2005·Nature Reviews. Immunology·Ke Shuai, Bin Liu
Jan 5, 2011·The Journal of Biological Chemistry·Toru KubotaKeiko Ozato
Jan 19, 2008·Clinical Microbiology Reviews·Elisabeth VercammenRudi Beyaert
Dec 30, 2011·American Journal of Respiratory Cell and Molecular Biology·Shasha TaoYin Chen
Sep 12, 2012·Cytokine & Growth Factor Reviews·Diede OudshoornMarjolein Kikkert
Apr 18, 2013·Molecular Systems Biology·David FurmanMark M Davis
Jun 10, 2006·Molecular Cell·Etienne Meylan, Jürg Tschopp
Oct 4, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaoli YuSongxiao Xu
Feb 22, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ran XiongJian-zhong Shao
Nov 8, 2012·Protein & Cell·Musheng Bao, Yong-Jun Liu
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicola TamassiaMarco A Cassatella
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Annie Bibeau-PoirierMarc J Servant
Apr 15, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu PanJun Zhang
Jan 19, 2021·Fish & Shellfish Immunology·Jun Soung Kwak, Ki Hong Kim
Mar 11, 2020·Developmental and Comparative Immunology·Shaopo ZuMing Liao
Jul 17, 2021·The Biochemical Journal·Jack A PrescottSimon J Cook
Jan 27, 2006·The American Journal of Pathology·Markus WörnleDetlef Schlöndorff

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis