journal cover

Picalm reduction exacerbates tau pathology in a murine tauopathy model

Acta Neuropathologica

Jan 12, 2020

Kunie AndoJean-Pierre Brion

Abstract

Genome-wide association studies (GWAS) have identified PICALM as one of the most significant susceptibility loci for late-onset Alzheimer's disease (AD) after APOE and BIN1. PICALM is a clathrin-adaptor protein and plays critical roles in clathrin-mediated endocytosis and in autophagy. ...read more

Mentioned in this Paper

Alzheimer's Disease
Frontotemporal Lobar Degeneration
Brain
Study
Neurologic Deficits
Phosphatidylinositol-Binding Clathrin Assembly Protein
Locus
Protein Expression
In Vivo
Clathrin-mediated Endocytosis
8
1
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Similar Papers Found In These Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Tau Aggregation: Genomics

Tau Aggregation is an important characteristic in some neurodegenerative disorders, including Alzheimer’s Disease. Discover the latest research using genomics to understand Tau Aggregation.

Neurogenetic Disorders

Neurogenetic disorders are caused by a defect in one or more genes affecting the differentiation and function of the neuroectoderm and its derivatives. Here is the latest research on neurogenetic disorders

Risk Factors for Neurodegeneration

Risk factors for neurodegeneration include trauma, lifestyle, and allelic variants of disease-associated genes with incomplete penetrance. Here is the latest research.

Alzheimer's Disease: Genes&Microglia

Genes and microglia are associated with the risk of developing and the progression of conditions such as Alzheimer's Disease (AD). Here are the latest discoveries pertaining to this disease.

Innate Immunity: Neurodegeneration

The innate immune system is a first line of defense against infection. Pathological states can occur if there is over activation of the innate immune system, particularly in the. The excessive activation of these cells can lead to inflammation and neurodegenerative diseases. Here is the latest research on innate immunity and neurodegeneration.

Frontotemporal Lobar Degeneration

Frontotemporal lobar degeneration or frontotemporal dementia refers to a group of uncommon disorders that occur as a result of progressive nerve cell loss in the frontal and temporal lobes of the brain. Here is the latest research.

Neurodegeneration: Autophagy

Given that progression of neurodegenerative diseases can be driven by aggregation of misfolded proteins, autophagic activity is through to modulate the severity of neurodegenerative diseases. Here is the latest research on the influence of autophagy on neurodegeneration.

Traumatic Encephalopathy

Traumatic Encephalopathy is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Tauopathies

Tauopathies are neurodegenerative disorders caused due to misfolding and aggregation of the tau protein in neurofibrillary tangles in the brain. Discover the latest research on tauopathies here.

Neurodegeneration: Genetics

Neurodegeneration is the progressive loss of structure or function of neurons, including neuronal death, and leads to several diseases, including Alzheimer’s and Parkinson’s. This feed focuses on the genetic alterations that underlie neurodegeneration.

Frontotemporal Dementia

Frontotemporal dementia (FTD) refers to disorders caused by progressive neuronal loss in the frontal and temporal lobes of the brain. Here is the latest research on FTD and FTD-associated disorders.

Lysosome & C9orf72

This feed focuses on the C9orf72 protein and its possible role in lysosome function and implication in frontotemporal dementia and amyotrophic lateral sclerosis

Alzheimer's Disease: Genetics

Alzheimer's disease is a chronic neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations here.

Diffuse Neurofibrillary Tangles with Calcification

Diffuse Neurofibrillary Tangles with Calcification (DNTC) is a rare form of presenile dementia. Here is the latest research.

Neurodegeneration: Endolysosome

This feed focuses on the role of the endolysosome, an organelle involved in protein degradation. Defects in the endolysosome may cause neurodegenerative diseases, such as Alzheimer’s Disease.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a chronic neurodegenerative disease. This feed focuses on the underlying role of Tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's.

Alzheimer's Disease: Animal models

Alzheimer's disease is a chronic neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Neuronal and Network Dysfunction In Neurodegeneration

This feed focuses on neuronal and network dysfunction in neurodegenerative disorders and the effects of tauopathies on synapses and memory.

© 2020 Meta ULC. All rights reserved

Picalm reduction exacerbates tau pathology in a murine tauopathy model

Acta Neuropathologica

Jan 12, 2020

Kunie AndoJean-Pierre Brion

PMID: 31925534

DOI: 10.1007/s00401-020-02125-x

Abstract

Genome-wide association studies (GWAS) have identified PICALM as one of the most significant susceptibility loci for late-onset Alzheimer's disease (AD) after APOE and BIN1. PICALM is a clathrin-adaptor protein and plays critical roles in clathrin-mediated endocytosis and in autophagy. ...read more

Mentioned in this Paper

Alzheimer's Disease
Frontotemporal Lobar Degeneration
Brain
Study
Neurologic Deficits
Phosphatidylinositol-Binding Clathrin Assembly Protein
Locus
Protein Expression
In Vivo
Clathrin-mediated Endocytosis
8
1

Similar Papers Found In These Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Tau Aggregation: Genomics

Tau Aggregation is an important characteristic in some neurodegenerative disorders, including Alzheimer’s Disease. Discover the latest research using genomics to understand Tau Aggregation.

Related Papers

Neuroreport

Amphiphysin-1 protein level changes associated with tau-mediated neurodegeneration

NeuroreportSeptember 15, 2012
Héctor J De Jesús-CortésIrving E Vega
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
/papers/picalm-reduction-exacerbates-tau-pathology-in-a/31925534