Piceatannol, a resveratrol derivative, promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and suppresses blood glucose levels in type 2 diabetic model db/db mice

Biochemical and Biophysical Research Communications
Miki MinakawaKazumi Yagasaki

Abstract

The skeletal muscle cells are one of the main sites of glucose uptake through glucose transporter 4 (GLUT4) in response to insulin. In muscle cells, 5' adenosine monophosphate-activated protein kinase (AMPK) is known as another GLUT4 translocation promoter. Natural compounds that activate AMPK have a possibility to overcome insulin resistance in the diabetic state. Piceatannol is a natural analog and a metabolite of resveratrol, a known AMPK activator. In this study, we investigate the in vitro effect of piceatannol on glucose uptake, AMPK phosphorylation and GLUT4 translocation to plasma membrane in L6 myocytes, and its in vivo effect on blood glucose levels in type 2 diabetic model db/db mice. Piceatannol was found to promote glucose uptake, AMPK phosphorylation and GLUT4 translocation by Western blotting analyses in L6 myotubes under a condition of insulin absence. Promotion by piceatannol of glucose uptake as well as GLUT4 translocation to plasma membrane by immunocytochemistry was also demonstrated in L6 myoblasts transfected with a glut4 cDNA-coding vector. Piceatannol suppressed the rises in blood glucose levels at early stages and improved the impaired glucose tolerance at late stages in db/db mice. These in vitro and i...Continue Reading

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Citations

Dec 15, 2012·European Journal of Nutrition·Myoung Jin SonKazumi Yagasaki
Dec 29, 2012·Journal of Agricultural and Food Chemistry·Alison D PawlusJean-Michel Mérillon
Sep 13, 2014·Nature Reviews. Drug Discovery·Frank MadeoGuido Kroemer
Jan 17, 2016·Biochemical and Biophysical Research Communications·Yukihiro OritaniShoji Takeuchi
Jan 14, 2016·Journal of Agricultural and Food Chemistry·Mohamed Ali SeyedKavitha Vijayaraghavan
Apr 4, 2015·Biological & Pharmaceutical Bulletin·Hiroko Uchida-MarukiTatsuhiko Ito
Sep 17, 2013·Molecular Nutrition & Food Research·Sun Hee CheongKazumi Yagasaki
Mar 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jia HaoTao Wang
Mar 29, 2014·Molecular Nutrition & Food Research·Chia-Yu HsuChing-Feng Weng
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Jul 17, 2015·Oxidative Medicine and Cellular Longevity·Mika ReinisaloReijo O Karjalainen
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Jan 6, 2021·Food & Function·Sakuka Tsukamoto-SenNobuharu L Fujii
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Oct 1, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hyo-Jin KimJin-Taek Hwang

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