Piceatannol attenuates D-GalN/LPS-induced hepatoxicity in mice: Involvement of ER stress, inflammation and oxidative stress

International Immunopharmacology
Jingjing WenDan Weng

Abstract

Piceatannol, a natural derivative of resveratrol, has been shown to exert similar anti-oxidant and anti-inflammatory effects as resveratrol. However, it remains unknown whether piceatannol has hepatoprotective effect against acute liver injury. In this study, we investigated the in vivo effect of piceatannol on D-GalN/LPS-induced fulminant hepatic failure (FHF), and its in vitro effect on ER stress-inducing drug thapsigargin (TG)-induced proinflammatory cytokines production and ROS release. Our results indicated that piceatannol markedly decreased the mortality rate, reduced the serum levels of alanine transaminase and aspartic aminotransferase, ameliorated the liver damage induced by D-GalN/LPS in mice. In addition, piceatannol reduced the expression of proinflammatory cytokines, including TNF-α, IL-1β and IL-6, the expression of ER stress markers CHOP and phosphorylated-IRE1α, and the generation of oxidative stress in D-GalN/LPS-treated mouse liver. In vitro results were consistent with in vivo observations, demonstrating that piceatannol suppressed the secretion of proinflammatory cytokines, inflammasome activation and the production of ROS induced by TG with or without LPS priming in J774A.1 macrophages. Our study proposes ...Continue Reading

Citations

Nov 30, 2019·Innate Immunity·Yisheng LuoLi Zhang
May 8, 2020·Molecular Medicine Reports·Shaohong WuJianhe Gan
Dec 15, 2019·Molecular Nutrition & Food Research·Yu DaiHai-Shu Lin
Dec 29, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jian ZouJian-Bo Wan
Dec 18, 2020·Frontiers in Microbiology·Guizhen WangTianqi Fang
Jun 17, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiaohong PangJinbin Wei
Aug 3, 2021·Journal of Food Biochemistry·Andressa Mara BaseggioMário Roberto Maróstica Júnior

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