Pickering-Emulsion for Liver Trans-Arterial Chemo-Embolization with Oxaliplatin

Cardiovascular and Interventional Radiology
F DeschampsAndrew C Larson

Abstract

Biodegradable polylactic-co-glycolic acid (PLGA) nanoparticles can adsorb at the water/oil interface to stabilize the emulsion (forming Pickering-emulsion). The purpose of this study was to compare the release profiles of oxaliplatin from Pickering-emulsion and Lipiodol-emulsion. Pickering-emulsions and Lipiodol-emulsions were both formulated with oxaliplatin (5 mg/mL) and Lipiodol (water/oil ratio: 1/3). For Pickering-emulsion only, PLGA nanoparticles (15 mg/mL) were dissolved into oxaliplatin before formulation. In vitro release of oxaliplatin from both emulsions was evaluated. Then, oxaliplatin was selectively injected into left hepatic arteries of 18 rabbits bearing VX2 liver tumors using either 0.5 mL Pickering-emulsion (n = 10) or 0.5 mL Lipiodol-emulsion (n = 8). In each group, half of the rabbits were killed at 1 h and half at 24 h. Mass spectrometry was used to quantify drug pharmacokinetics in blood and resulting tissue (tumors, right, and left livers) oxaliplatin concentrations. Pickering-emulsion demonstrated a slow oxaliplatin release compared to Lipiodol-emulsion (1.5 ± 0.2 vs. 12.0 ± 6% at 1 h and 15.8 ± 3.0 vs. 85.3 ± 3.3% at 24 h) during in vitro comparison studies. For animal model studies, the plasmatic peak ...Continue Reading

References

Jun 29, 2004·World Journal of Gastroenterology : WJG·Xiao-Feng LiaoGeng Tian
Jul 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michel DucreuxUNKNOWN gastrointestinal group of the Federation Nationale des Centres de Lutte Contre le Cancer
Dec 20, 2011·Journal of Vascular and Interventional Radiology : JVIR·Ron C GabaReed A Omary
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Jun 24, 2017·World Journal of Clinical Oncology·Giammaria FiorentiniStefano Guadagni
Aug 5, 2017·Cardiovascular and Interventional Radiology·F DeschampsT de Baère

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Citations

Jun 21, 2019·Cardiovascular and Interventional Radiology·Olivier PellerinBoris Guiu
Oct 30, 2020·Materials·Rafał Bielas, Arkadiusz Józefczak
Jul 12, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Claire AlbertNicolas Huang
Oct 24, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Claire AlbertFlorence Agnely

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