Picoliter-volume inkjet printing into planar microdevice reservoirs for low-waste, high-capacity drug loading.

Bioengineering & Translational Medicine
Cade B FoxTejal A Desai

Abstract

Oral delivery of therapeutics is the preferred route for systemic drug administration due to ease of access and improved patient compliance. However, many therapeutics suffer from low oral bioavailability due to low pH and enzymatic conditions, poor cellular permeability, and low residence time. Microfabrication techniques have been used to create planar, asymmetric microdevices for oral drug delivery to address these limitations. The geometry of these microdevices facilitates prolonged drug exposure with unidirectional release of drug toward gastrointestinal epithelium. While these devices have significantly enhanced drug permeability in vitro and in vivo, loading drug into the micron-scale reservoirs of the devices in a low-waste, high-capacity manner remains challenging. Here, we use picoliter-volume inkjet printing to load topotecan and insulin into planar microdevices efficiently. Following a simple surface functionalization step, drug solution can be spotted into the microdevice reservoir. We show that relatively high capacities of both topotecan and insulin can be loaded into microdevices in a rapid, automated process with little to no drug waste.

References

Dec 31, 1997·Journal of Pharmaceutical and Biomedical Analysis·S B CraigK Patel
Sep 28, 1998·Biochimica Et Biophysica Acta·Y PommierD Strumberg
Apr 2, 2003·Nature Reviews. Drug Discovery·Michael Goldberg, Isabel Gomez-Orellana
Jun 15, 2004·Biomaterials·Tao XuThomas Boland
Apr 2, 2005·Nature Reviews. Drug Discovery·Sven Frokjaer, Daniel E Otzen
Jun 30, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Alexander BietschChristoph Gerber
Jul 5, 2005·Drug Discovery Today·Sarah L Tao, Tejal A Desai
Nov 9, 2007·Current Opinion in Biotechnology·Rahul Palchaudhuri, Paul J Hergenrother
Feb 16, 2010·Diabetes, Obesity & Metabolism·Harish IyerManish Verma
Mar 25, 2010·Analytical Chemistry·Giuseppe Arrabito, Bruno Pignataro
Jun 5, 2012·Biomicrofluidics·Nick R GlassJames R Friend
Nov 8, 2012·Nature Communications·Mitsuhiro IkawaTatsuo Hasegawa
Oct 8, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Paolo MarizzaAnja Boisen
Apr 9, 2014·Advanced Healthcare Materials·Hariharasudhan D ChirraTejal A Desai
May 23, 2014·Expert Opinion on Drug Delivery·Lindsey A SharpeNicholas A Peppas
Aug 12, 2014·Nature Reviews. Drug Discovery·Samir MitragotriRobert Langer
Sep 16, 2014·Current Pharmaceutical Biotechnology·Cade B FoxTejal A Desai
Mar 17, 2015·International Journal of Pharmaceutics·Ronan DalyIan M Hutchings
Jun 9, 2016·ACS Nano·Cade B FoxTejal A Desai
Jul 2, 2016·The Journal of Pharmacy and Pharmacology·Chun Y WongCrispin R Dass

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Citations

Apr 3, 2019·Macromolecular Bioscience·Chiara MazzoniAnja Boisen
Apr 21, 2019·Pharmaceutical Research·Cameron L NemethTejal A Desai
Feb 6, 2020·Micromachines·Adam S OpalskiPiotr Garstecki
Oct 2, 2019·Bioengineering & Translational Medicine·Samir Mitragotri
Jan 10, 2018·Bioengineering & Translational Medicine·Pankaj Karande
Jul 6, 2018·Lab on a Chip·Line Hagner NielsenAnja Boisen
Feb 26, 2020·Genome Biology·Jesse Q ZhangAdam R Abate
May 18, 2020·Advanced Drug Delivery Reviews·Nikolaj Kofoed MandsbergSarvesh Kumar Srivastava
Mar 13, 2021·International Journal of Pharmaceutics·Wai-Houng ChouJavier O Morales
Mar 30, 2021·ACS Omega·Nikolaj Kofoed MandsbergEn Te Hwu
Jul 17, 2021·Biomedical Microdevices·Zarmeena AbidStephan S Keller
Jun 10, 2019·ACS Biomaterials Science & Engineering·Chiara MazzoniAnja Boisen
Aug 15, 2021·Advanced Drug Delivery Reviews·Connor O'FarrellHannah Batchelor

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Methods Mentioned

BETA
scanning electron microscopy
Fluorescence microscopy

Software Mentioned

CyQUANT

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