Abstract
Human enteroviruses are the most common cause of viral meningitis. Viral-bacterial interaction may affect the clinical course and outcome of bacterial meningitis. In Africa, viruses might be responsible for 14-25% of all meningitis cases. However, only few studies from Africa have reported detection of viruses in the cerebrospinal fluid (CSF) or mixed viral-bacterial infections of the central nervous system (CNS). The aim of the present study was to investigate the presence of picornaviruses in the CSF of children suffering from meningitis in Luanda, Angola. The study included 142 consecutive children enrolled in a prospective study of bacterial meningitis in Luanda between 2005 and 2006, from whom a CSF sample was available. CSF samples were obtained at hospital admission, stored in a deep-freeze, and transported to Finland for testing by real-time PCR for picornaviruses. Enteroviruses were detected in 4 (3%) of 142 children with presumed bacterial meningitis. A 5-month-old girl with rhinovirus and Haemophilus influenzae meningitis recovered uneventfully. An 8-year-old girl with human enterovirus and pneumococcal meningitis developed no sequelae. A 2-month-old girl with human enterovirus and malaria recovered quickly. A 7-mont...Continue Reading
References
Oct 1, 1993·Epidemiology and Infection·J P McIntyre, G A Keen
Oct 24, 1998·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·M HosoyaH Suzuki
Jun 14, 2001·Lancet·J A BerkleyC R Newton
May 29, 2004·Current Opinion in Infectious Diseases·Carol Beadling, Mark K Slifka
Dec 21, 2004·The Journal of Infectious Diseases·Adriana WeinbergKenneth L Tyler
May 2, 2007·Current Opinion in Infectious Diseases·Bonita E Lee, H Dele Davies
Jan 24, 2008·Epidemiology and Infection·A G S C JansenE Hak
Jun 6, 2008·Journal of Clinical Microbiology·W Allan NixM Steven Oberste
Jun 19, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Katja C WolthersDasja Pajkrt
Jun 21, 2008·Lancet Neurology·Matthew Scarborough, Guy E Thwaites
May 22, 2009·The Journal of Infectious Diseases·H HarvalaP Simmonds
Dec 3, 2009·The Pediatric Infectious Disease Journal·Jay D WengerThomas Hennessy
Mar 2, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Soile BlomqvistMerja Roivainen
May 10, 2011·The Lancet Infectious Diseases·Tuula PelkonenHeikki Peltola
Dec 1, 2009·Viruses·Carita Savolainen-KopraMerja Roivainen
Citations
Apr 22, 2014·The Lancet Global Health·Macpherson MallewaTom Solomon
Jan 10, 2013·Genetic Testing and Molecular Biomarkers·Silva SlikaRami Mahfouz
Nov 27, 2014·BMC Infectious Diseases·Moses LamanLaurens Manning
Feb 28, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Kelvin K W ToKwok-Yung Yuen
Jun 15, 2016·Enfermedades infecciosas y microbiología clínica·Itziar Angulo LópezElsa Ots Ruiz
Jul 13, 2013·Tropical Doctor·Girish C Bhatt
Nov 12, 2014·The Pediatric Infectious Disease Journal·Isabel AguadoMaría Cabrerizo
Feb 27, 2014·The Pediatric Infectious Disease Journal·Irmeli RoineAnne Pitkäranta
Jan 20, 2021·The Pediatric Infectious Disease Journal·Noriko SomaAkihiko Saitoh
Mar 26, 2021·Infection and Drug Resistance·Alene GetenehWude Mihret
Aug 10, 2020·Virus Research·Antonio Humberto Angel-AmbrocioRosa María Wong-Chew