Picornaviruses in cerebrospinal fluid of children with meningitis in Luanda, Angola

Journal of Medical Virology
Tuula PelkonenAnne Pitkäranta

Abstract

Human enteroviruses are the most common cause of viral meningitis. Viral-bacterial interaction may affect the clinical course and outcome of bacterial meningitis. In Africa, viruses might be responsible for 14-25% of all meningitis cases. However, only few studies from Africa have reported detection of viruses in the cerebrospinal fluid (CSF) or mixed viral-bacterial infections of the central nervous system (CNS). The aim of the present study was to investigate the presence of picornaviruses in the CSF of children suffering from meningitis in Luanda, Angola. The study included 142 consecutive children enrolled in a prospective study of bacterial meningitis in Luanda between 2005 and 2006, from whom a CSF sample was available. CSF samples were obtained at hospital admission, stored in a deep-freeze, and transported to Finland for testing by real-time PCR for picornaviruses. Enteroviruses were detected in 4 (3%) of 142 children with presumed bacterial meningitis. A 5-month-old girl with rhinovirus and Haemophilus influenzae meningitis recovered uneventfully. An 8-year-old girl with human enterovirus and pneumococcal meningitis developed no sequelae. A 2-month-old girl with human enterovirus and malaria recovered quickly. A 7-mont...Continue Reading

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Citations

Apr 22, 2014·The Lancet Global Health·Macpherson MallewaTom Solomon
Feb 28, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Kelvin K W ToKwok-Yung Yuen
Jun 15, 2016·Enfermedades infecciosas y microbiología clínica·Itziar Angulo LópezElsa Ots Ruiz
Nov 12, 2014·The Pediatric Infectious Disease Journal·Isabel AguadoMaría Cabrerizo
Feb 27, 2014·The Pediatric Infectious Disease Journal·Irmeli RoineAnne Pitkäranta
Jan 20, 2021·The Pediatric Infectious Disease Journal·Noriko SomaAkihiko Saitoh
Aug 10, 2020·Virus Research·Antonio Humberto Angel-AmbrocioRosa María Wong-Chew

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