Picosecond and Terahertz Perturbation of Interfacial Water and Electropermeabilization of Biological Membranes

The Journal of Membrane Biology
P Thomas VernierAndrei G Pakhomov

Abstract

Non-thermal probing and stimulation with subnanosecond electric pulses and terahertz electromagnetic radiation may lead to new, minimally invasive diagnostic and therapeutic procedures and to methods for remote monitoring and analysis of biological systems, including plants, animals, and humans. To effectively engineer these still-emerging tools, we need an understanding of the biophysical mechanisms underlying the responses that have been reported to these novel stimuli. We show here that subnanosecond (≤500 ps) electric pulses induce action potentials in neurons and cause calcium transients in neuroblastoma-glioma hybrid cells, and we report complementary molecular dynamics simulations of phospholipid bilayers in electric fields in which membrane permeabilization occurs in less than 1 ns. Water dipoles in the interior of these model membranes respond in less than 1 ps to permeabilizing electric potentials by aligning in the direction of the field, and they re-orient at terahertz frequencies to field reversals. The mechanism for subnanosecond lipid electropore formation is similar to that observed on longer time scales-energy-minimizing intrusions of interfacial water into the membrane interior and subsequent reorganization of...Continue Reading

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Citations

Jan 10, 2016·Biochimica Et Biophysica Acta·Sonja A Kirsch, Rainer A Böckmann
Aug 3, 2016·Biochemistry and Biophysics Reports·Iurii SemenovAndrei G Pakhomov
Mar 30, 2018·Expert Review of Cardiovascular Therapy·Alan SugrueSamuel Asirvatham
Jul 17, 2016·Medical & Biological Engineering & Computing·C MerlaM Liberti
Aug 11, 2018·The Journal of Membrane Biology·Jingchao TangYubin Gong
May 15, 2020·The Journal of Membrane Biology·Jingchao TangYubin Gong
Apr 15, 2019·Biochimica Et Biophysica Acta. Biomembranes·Esin B Sözer, P Thomas Vernier
Jul 28, 2020·Bioelectrochemistry·Andrei G Pakhomov, Olga N Pakhomova
Feb 15, 2020·Biochimica Et Biophysica Acta. Biomembranes·Jingchao TangYubin Gong
May 5, 2021·Annals of the New York Academy of Sciences·Federico BertagnaKamalan Jeevaratnam

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