Picroliv and its components kutkoside and picroside I protect liver against galactosamine-induced damage in rats

Pharmacology & Toxicology
Y DwivediB N Dhawan

Abstract

D-Galactosamine (800 mg/kg, intraperitoneally) caused significant decrease in the activities of 5'-nucleotidase, glucose-6-phosphatase and cytochrome P450 and increase in activities of gamma-glutamyl transpeptidase, succinate dehydrogenase, acid phosphatase and acid ribonuclease in liver after 24 hr. The levels of RNA, protein and glycogen decreased while total lipids, phospholipids, cholesterol and lipid peroxides increased. It also increased the serum levels of transaminases, alkaline phosphatase and bilirubin while protein concentration decreased significantly. Oral administration of Picroliv (12 mg/kg/day for 7 days), a standardised iridoid glycoside fraction of Picrorhiza kurroa, significantly prevented the biochemical changes in liver and serum of galactosamine-toxicated rats. Kutkoside (12 mg/kg/day for 7 days) also protected against changes in most of the hepatic and serum constituents studied. Another iridoid glycoside from Picroliv, Picroside I, at the same dose level could only prevent toxicant-induced changes in acid phosphatase, phospholipids and lipid peroxides in liver and alkaline phosphatase in serum. Mixture of Picroside I and Kutkoside in the ratio of 1:1.5 at 12 mg/kg dose elicited lesser response than Picro...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
May 1, 1991·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Y DwivediB N Dhawan
Jan 1, 1987·The International Journal of Biochemistry·D H PetkovaK S Koumanov
Oct 1, 1968·Experimental and Molecular Pathology·D KepplerK Decker
Mar 1, 1971·Hoppe-Seyler's Zeitschrift für physiologische Chemie·K DeckerW Domschke
Oct 1, 1952·The Biochemical Journal·E C SLATER, W D BORNER
Apr 1, 1957·Archives of Biochemistry and Biophysics·R MONTGOMERY
Jul 1, 1957·American Journal of Clinical Pathology·S REITMAN, S FRANKEL

Citations

Dec 3, 2005·Evidence-based Complementary and Alternative Medicine : ECAM·Bhushan PatwardhanNarendra Bhatt
Dec 4, 2008·Fundamental & Clinical Pharmacology·C Girish, Suresh Chandra Pradhan
Jun 3, 2017·Critical Reviews in Food Science and Nutrition·Kumar GanesanBaojun Xu
Nov 8, 2005·Human & Experimental Toxicology·N YadavS Khandelwal
Dec 23, 2017·Archives of Physiology and Biochemistry·Walid Hamdy El-Tantawy, Abeer Temraz
Jun 25, 2020·Metabolomics : Official Journal of the Metabolomic Society·Manglesh KumariRajiv Kumar

Related Concepts

Kutkin
Transaminases
Metazoa
Cinnamates
Galactosamine
Glycosides
Liver
Phosphoric Monoester Hydrolases
Vanillic Acid
5'-NUCLEOTIDASE

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.