Jan 30, 2004

Picrotoxin increased acetylcholine release from rat cultured embryonic septal neurons

Neuroscience Letters
Takeshi SuzukiK Kawashima

Abstract

GABA is a major inhibitory neurotransmitter in the mature mammalian brain. In the early stages of brain development, it has been reported that GABA(A) receptor stimulation and the associated increase in Cl(-) conductance lead to membrane depolarization. In this study, we tested the effects of picrotoxin, a GABA(A) receptor Cl(-) channel blocker, on spontaneously released acetylcholine (ACh) from cultured rat embryonic septal cells. Picrotoxin increased spontaneously released ACh. These results indicate that blockade of GABA-activated Cl(-) channel increases neuronal excitability even in an early stage of the development.

  • References11
  • Citations1

Citations

Mentioned in this Paper

Embryo
Coculture Techniques
Neurons
Picrotoxin
GABA-A Receptor
Neuronal
Neurotransmitters
Rats, Wistar
Acetylcholine Sulfate (1: 1)
Excitability

About this Paper

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.