Picrotoxin produces a "central" pain-like syndrome when microinjected into the somato-motor cortex of the rat

Physiology & Behavior
J L Olivéras, J Montagne-Clavel

Abstract

In this study, we report the possibility of producing marked electrocorticographic changes and "pain-like" reactions, when the GABAA antagonist picrotoxin is microinjected unilateraly into the rat somato-motor Sml cortex in the region of the hind paw. After the microinjection, we observed continuous seizure isolated spikes, spikes-and-waves, bursts, and pain-like reactions, almost exclusively confined to the hind paw. These reactions considered of lifting off the floor, licking of the paw palm or digits, biting, paw tremors, and a peculiar paw position that we called "turn-in" paw. We also noted other behaviors, such as "limping," "neglected" paw, or rearing. The "pain-like" character of these manifestations was suggested by the fact that similar qualitative and quantitative data occurred consequent to the administration of 2.5% diluted formalin into the palm of the hind paw in different rats. Bringing together the electrocorticographic events and the behavioral reactions produced by Sml picrotoxin indicated that there was no obvious correlation between the phenomena, except that the tremor was always associated with the bursts. Sensory denervation of the hind paw, produced by sciatic and saphenous nerve transections, did not s...Continue Reading

References

Sep 15, 1977·The Journal of Comparative Neurology·S P Wise, E G Jones
Mar 15, 1978·The Journal of Comparative Neurology·S P Wise, E G Jones
Jul 1, 1992·Biulleten' eksperimental'noĭ biologii i meditsiny·G N KryzhanovskiĭV A Zinkevich
Feb 1, 1988·Neurology·E Trevathan, G D Cascino
Jan 1, 1987·Applied Neurophysiology·D E Richardson
Mar 1, 1986·Brain Research·E J NeafseyR R Terreberry
Nov 1, 1974·Biulleten' eksperimental'noĭ biologii i meditsiny·G N KryzhanovskiĭE I Danilova
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·R M PostP W Gold
Sep 1, 1984·Pain·M AlrejaS K Manchanda
Sep 1, 1983·Brain : a Journal of Neurology·G B Young, W T Blume
May 15, 1994·The Journal of Comparative Neurology·J Li, H D Schwark
May 1, 1995·Acta Neurologica Scandinavica·S Balkan
Jul 1, 1993·Pharmacology, Biochemistry, and Behavior·J ThomasR D Olson
Oct 29, 1993·Science·M SteriadeT J Sejnowski
Apr 1, 1993·Clinical EEG (electroencephalography)·P K Sahota, M A Stacy

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Citations

Feb 13, 1999·Progress in Neurobiology·M J Millan
Sep 17, 2013·The Journal of Pain : Official Journal of the American Pain Society·Nicholas S GregoryKathleen A Sluka
Jul 5, 2019·Toxicologic Pathology·Saravanan KaliyaperumalCharles Dean

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