Nov 1, 1975

'Picture frame' fibres in a carrier of the trait for malignant hyperpyrexia

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
H IsaacsM Badenhorst


A member of a family which was known to be susceptible to malignant hyperpyrexia, who was identified as a carrier by the presence of an elevated serum creatine-phosphokinase, has been investigated further. Muscle was examined biochemically, and the study included the sarcoplasmic ATPase-activity, actinomycin, Mg2+ ATPase activity, ATP, phosphocreatine and glucose-6-phosphate. In addition, the calcium uptake by the sarcoplasmic reticulum was studied. The histochemical analysis of the muscle revealed the presence of a new fibre type characterised by a dense rim of ATPase activity, which gives the impression of a 'picture-frame'. Ultramicroscopic study revealed changes in the mitochondria and areas of myofibrillar disruption with swelling of the sarcoplasmic reticulum.

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Mentioned in this Paper

Attention Deficit and Disruptive Behavior Disorders
Electron Microscopy
Sarcoplasmic Reticulum
DNA-dependent ATPase
Malignant Hyperpyrexia due to Anesthesia

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