PMID: 795Nov 1, 1975

'Picture frame' fibres in a carrier of the trait for malignant hyperpyrexia

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
H IsaacsM Badenhorst


A member of a family which was known to be susceptible to malignant hyperpyrexia, who was identified as a carrier by the presence of an elevated serum creatine-phosphokinase, has been investigated further. Muscle was examined biochemically, and the study included the sarcoplasmic ATPase-activity, actinomycin, Mg2+ ATPase activity, ATP, phosphocreatine and glucose-6-phosphate. In addition, the calcium uptake by the sarcoplasmic reticulum was studied. The histochemical analysis of the muscle revealed the presence of a new fibre type characterised by a dense rim of ATPase activity, which gives the impression of a 'picture-frame'. Ultramicroscopic study revealed changes in the mitochondria and areas of myofibrillar disruption with swelling of the sarcoplasmic reticulum.

Related Concepts

DNA-dependent ATPase
Genetic Carriers
Hydrogen-Ion Concentration
Malignant Hyperpyrexia due to Anesthesia
Electron Microscopy

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.