PID-1 is a novel factor that operates during 21U-RNA biogenesis in Caenorhabditis elegans

Genes & Development
Bruno F M de AlbuquerqueRené F Ketting

Abstract

The Piwi-piRNA pathway represents a small RNA-based mechanism responsible for the recognition and silencing of invading DNA. Biogenesis of piRNAs (21U-RNAs) is poorly understood. In Caenorhabditis elegans, the piRNA-binding Argonaute protein PRG-1 is the only known player acting downstream from precursor transcription. From a screen aimed at the isolation of piRNA-induced silencing-defective (Pid) mutations, we identified, among known Piwi pathway components, PID-1 as a novel player. PID-1 is a mostly cytoplasmic, germline-specific factor essential for 21U-RNA biogenesis, affecting an early step in the processing or transport of 21U precursor transcripts. We also show that maternal 21U-RNAs are essential to initiate silencing.

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Citations

Jan 2, 2015·Scientific Reports·Daniel SchottCraig P Hunter
Mar 10, 2015·Annual Review of Biochemistry·Yuka W IwasakiHaruhiko Siomi
Jun 30, 2015·Current Molecular Biology Reports·Yung-Chia Ariel Chen, Alexei A Aravin
Jun 25, 2014·Frontiers in Genetics·Li-Ling Chak, Katsutomo Okamura
Dec 21, 2018·Genes & Development·Chenchun WengEric A Miska
Jan 18, 2019·Non-coding RNA·Miguel Vasconcelos AlmeidaRené F Ketting
May 31, 2019·Genes & Development·Ricardo J Cordeiro RodriguesRené F Ketting
Jun 1, 2019·Annual Review of Genetics·Natasha E Weiser, John K Kim
Mar 10, 2021·Translational Neurodegeneration·Xiaobing Huang, Garry Wong
Sep 4, 2014·Development·Eva-Maria Weick, Eric A Miska
Aug 21, 2021·Genes & Development·Cecilia Perez-BorrajeroSebastian Falk
Sep 24, 2021·Nature Communications·Xiaoyang WangChao Xu

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