PiggyBac-ing on a primate genome: novel elements, recent activity and horizontal transfer.

Genome Biology and Evolution
Heidi J T PagánDavid A Ray

Abstract

To better understand the extent of Class II transposable element activity in mammals, we investigated the mouse lemur, Microcebus murinus, whole genome shotgun (2X) draft assembly. Analysis of this strepsirrhine primate extended previous research that targeted anthropoid primates and found no activity within the last 37 Myr. We tested the hypothesis that members of the piggyBac Class II superfamily have been inactive in the strepsirrhine lineage of primates during the same period. Evidence against this hypothesis was discovered in the form of three nonautonomous piggyBac elements with activity periods within the past 40 Myr and possibly into the very recent past. In addition, a novel family of piggyBac transposons was identified, suggesting introduction via horizontal transfer. A second autonomous element was also found with high similarity to an element recently described from the little brown bat, Myotis lucifugus, further implicating horizontal transfer in the evolution of this genome. These findings indicate a more complex history of transposon activity in mammals rather than a uniform shutdown of Class II transposition, which had been suggested by analyses of more common model organisms.

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Citations

Dec 4, 2010·Genome Biology and Evolution·Peter A NovickStéphane Boissinot
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Feb 19, 2020·Genome Biology and Evolution·Wencheng ZongChengyi Song

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Datasets Mentioned

BETA
ABDC00000000
HM133643-HM133648

Methods Mentioned

BETA
PCR
Assay

Software Mentioned

CENSOR
PILER
custom Perl scripts
TBlastN
MEGA4
RepeatMasker
MUSCLE
BlastN
custom Perl script
BlastX

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