PMID: 9170157Feb 1, 1997Paper

Pigment cell research: what directions?

Pigment Cell Research
G Prota

Abstract

Over the past few years, pigment cell research has experienced unprecedented impetus in practically all areas. However, as is usually the case in periods of rapid development, several critical issues buried under the glitz of recent success are more or less the same as they have been for many years. Persisting misconceptions and scientific prejudices also contribute to cloud many issues. It appears, for example, that the common perception of melanocyte function is still biased by the traditional concept of a pigment producing cell. In fact, in addition to melanin, epidermal melanocytes are known to produce and excrete a number of melanin-related metabolites, such as DHI and DHICA, which appear to play a critical role in protection of epidermal tissues against toxic oxygen radical species as well as in inflammatory and immune reactions. Another major gap concerns the pheomelanin pigmentary system. This has traditionally been a neglected area of research in spite of compelling evidence for the abnormal susceptibility of red heads to sun damage and skin cancer. An increased attention to the peculiar biological and biochemical features of the pheomelanin forming cells will expectedly open new vistas on the UV susceptibility trait a...Continue Reading

References

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Citations

Aug 6, 2005·Experimental Eye Research·Kazunari HigaKazuo Tsubota
Sep 3, 2002·Survey of Ophthalmology·Laszlo Z Bito
Aug 12, 1998·Clinics in Dermatology·A Slominski, J Pawelek
Oct 24, 2002·Melanoma Research·R A Sturm
Jan 25, 2006·Melanoma Research·Rangaprasad Sarangarajan, Shireesh P Apte
Sep 11, 2009·Melanoma Research·Vittoria MarescaMauro Picardo
Jan 19, 2006·The Journal of Investigative Dermatology·Vittoria MarescaMauro Picardo
Sep 3, 2003·Pigment Cell Research·Jesús Sánchez MásJosé Carlos García-Borrón
Jul 17, 2009·Veterinary Ophthalmology·Thamara A CafaroHoracio M Serra
Jan 30, 2009·International Journal of Cosmetic Science·J A Swift
Feb 11, 2014·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Toru KojimaKazuhiko Fukushima
Mar 20, 2015·Pigment Cell & Melanoma Research·Vittoria MarescaMauro Picardo
Apr 15, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Taketsugu TadokoroVincent J Hearing
Jan 4, 2020·Clinics in Dermatology·Vishal Gupta, Vinod Kumar Sharma

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