PMID: 3769517Oct 1, 1986Paper

Pigment changes in human skin after cryotherapy

Cryobiology
S M BurgeR P Dawber

Abstract

We have investigated the changes in pigmentation and melanocyte distribution in human skin after a standardized freeze injury. All lesions developed hypopigmentation with a peripheral rim of hyperpigmentation. Abnormalities in pigmentation persisted for at least 6 months. Hyperpigmentation was predominantly an epidermal phenomenon. After brief freezes, hypopigmentation persisted despite the presence of functional melanocytes. After prolonged freezes, the consistent finding was an absence of melanosomes in keratinocytes, although melanocytes were present. We conclude that prolonged changes in skin color are frequent after brief freezes and that hypopigmentation is not synonymous with an absence of melanocytes. This suggests that hypopigmentation after the cryosurgical treatment of malignant melanocytic tumors may not equate with cure.

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Citations

Oct 29, 2003·Cryobiology·Mary F OttersonAlonzo P Walker
Feb 5, 2000·British Journal of Plastic Surgery·S H LiewC Linge
Apr 30, 2002·The American Journal of Dermatopathology·J Andrew CarlsonAndrzej Slominski
Nov 24, 1999·Journal of the European Academy of Dermatology and Venereology : JEADV·A T Sheridan, R P Dawber
Oct 26, 2007·Pediatric Dermatology·Maureen Connolly, Cameron T C Kennedy
Aug 2, 2012·American Journal of Clinical Dermatology·Lauren L Levy, Joshua A Zeichner
Apr 21, 2016·Lasers in Surgery and Medicine·Vasanop VachiramonKumutnart Chanprapaph
Apr 11, 2012·Thérapie·Aurélie Terrier-LengletMichel Andréjak
Jun 5, 2013·The Journal of Investigative Dermatology·Claire Q F WangJames G Krueger
Jan 15, 2009·The British Journal of Dermatology·B ArunJ P Byrne
Jun 16, 2011·Clinical and Experimental Dermatology·V Vachiramon, K Thadanipon
May 1, 1988·Clinical and Experimental Dermatology·R Dawber
Nov 28, 2018·Lasers in Surgery and Medicine·Aria Vazirnia, Arisa E Ortiz
Jan 25, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·Y Har-ShaiC C Zouboulis
Feb 1, 1987·The Journal of Investigative Dermatology·S M BurgeR P Dawber

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