Pigment Dispersing Factors and Their Cognate Receptors in a Crustacean Model, With New Insights Into Distinct Neurons and Their Functions

Frontiers in Neuroscience
Jodi L AlexanderSimon G Webster

Abstract

Pigment dispersing factors (PDFs, or PDHs in crustaceans) form a structurally related group of neuropeptides found throughout the Ecdysozoa and were first discovered as pigmentary effector hormones in crustaceans. In insects PDFs fulfill crucial neuromodulatory roles, most notably as output regulators of the circadian system, underscoring their central position in physiological and behavioral organization of arthropods. Intriguingly, decapod crustaceans express multiple isoforms of PDH originating from separate genes, yet their differential functions are still to be determined. Here, we functionally define two PDH receptors in the crab Carcinus maenas and show them to be selectively activated by four PDH isoforms: PDHR 43673 was activated by PDH-1 and PDH-2 at low nanomolar doses whilst PDHR 41189 was activated by PDH-3 and an extended 20 residue e-PDH. Detailed examination of the anatomical distribution of all four peptides and their cognate receptors indicate that they likely perform different functions as secreted hormones and/or neuromodulators, with PDH-1 and its receptor 43,673 implicated in an authentic hormonal axis. PDH-2, PDH-3, and e-PDH were limited to non-neurohemal interneuronal sites in the CNS; PDHR 41189 was la...Continue Reading

References

Jul 19, 1976·Biochimica Et Biophysica Acta·P Fernlund
Dec 30, 1992·Biochemical and Biophysical Research Communications·J M KleinW M Weidemann
Oct 14, 1967·Nature·M StefaniniL Zamboni
Feb 1, 1993·Chronobiology International·H AréchigaL Rodríguez-Sosa
Apr 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·J LohrH Dircksen
May 31, 1993·Annals of the New York Academy of Sciences·K R Rao, J P Riehm
Dec 1, 1995·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·D P De Kleijn, F Van Herp
Nov 5, 1998·Proceedings. Biological Sciences·H Aréchiga, L Rodríguez-Sosa
Jun 20, 2001·Journal of Neurochemistry·L LiJ V Sweedler
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 13, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·M A VerdeB Fuentes-Pardo
Jun 16, 2009·General and Comparative Endocrinology·Mingming MaLingjun Li
Sep 5, 2009·Chronobiology International·Jeremy M SullivanDavid C Sandeman
Jun 3, 2010·Frontiers in Bioscience (Landmark Edition)·Johannes Strauss, Heinrich Dircksen
Nov 3, 2010·Progress in Neurobiology·E MeelkopT Janssen
Nov 16, 2010·General and Comparative Endocrinology·Andrew E ChristiePetra H Lenz
Feb 5, 2011·Science·John K ColbourneJeffrey L Boore
Mar 3, 2011·Cellular and Molecular Life Sciences : CMLS·Johannes StraussHeinrich Dircksen
Jun 5, 2012·Nucleic Acids Research·Panu ArtimoHeinz Stockinger
Dec 12, 2012·Frontiers in Endocrinology·Jelle CaersLiliane Schoofs
Dec 19, 2012·General and Comparative Endocrinology·Simon George WebsterJasmine Heloise Sharp
May 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Gáspár Jékely
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Olivier Mirabeau, Jean-Stéphane Joly

❮ Previous
Next ❯

Datasets Mentioned

BETA
SRX3280830-846
PRJNA400568
GFX00000000
MN629919
MN629920
MN629921

Methods Mentioned

BETA
PCR
transfections
Fusion
dissection
dissections

Software Mentioned

Mascot
SigmaPlot
Geneious
ExPASy translate
MikroWin
Zen Black edition
CorelDraw
NetNGlyc
tBLASTn
Geneious V8 Tree builder

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.