PMID: 7089489Mar 1, 1982Paper

Pigment mutations in the mouse which also affect lysosomal functions lead to suppressed natural killer cell activity

Scandinavian Journal of Immunology
A OrnL G Lundin

Abstract

The impact of five pigment mutations in the mouse on natural killer (NK) activity was examined in inbred strains congenic for the respective mutation. Whereas the nature of pigmentation disorder was similar in the five mutant strains (beige, pallid, reduced pigmentation, pale ear, and sepia), all mutations except sepia also led to a significant change in lysosomal enzyme activities in the kidney. A significant reduction in NK activity was observed in the four strains with lysosomal impact, whereas homozygous sepia mice displayed normal NK activity. The pigment mutations analysed are located on different chromosomes and fail to cross-interact negatively with each other in the heterozygous mice. This would indicate that pigment mutations with a parallel impact on lysosomal enzyme activities probably always result in a reduction in natural killer cell activity.

References

Jan 1, 1979·Immunological Reviews·R Kiessling, H Wigzell
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Feb 1, 1977·Biochemical Genetics·E M Håkansson, L G Lundin
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Citations

Dec 1, 1989·Experientia·F AhmedJ G Shire
Mar 15, 1983·Experientia·J R StarkeyS S Ristow
Jul 8, 2000·Trends in Cell Biology·N W Andrews
Jul 15, 1999·Clinical and Experimental Immunology·N NilssonH Carlsten
Nov 1, 1980·Immunology Today·J Roder, T Haliotis
May 29, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M D LaurentiH Goto
May 19, 1998·Pigment Cell Research·R T SwankL Feng
Jan 1, 1992·Pigment Cell Research·S J OrlowJ M Pawelek

Related Concepts

Natural Immunosuppression
Resistance, Natural
Kidney
Natural Killer Cells
Liver
Lysosomes
Schamberg Disease
Spleen

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