Abstract
Pigmentary degeneration of the retina was induced by a single intraperitoneal injection of 75 mg/kg of N-methyl-N-nitrosourea (MNU) in female Brown-Norway colored rats at 50 days of age, which were then observed at 24, 48 and 72 h and 7, 21, 35 and 150 days after the treatment. MNU-treated rats showed selective destruction of the photoreceptor cells by an apoptotic mechanism 24 h after the treatment, and the destruction was completed by day 7. During the photoreceptor cell degeneration, proliferation of Müller cells and infiltration of macrophages was prominent 72 h and 21 days after the treatment, respectively. Müller cell proliferation and macrophage infiltration corresponded to degenerative photoreceptor cell phagocytosis, and proliferating Müller cell processes responded to stabilize the damaged retina. Pigment epithelial cell detachment from the Bruch's membrane was seen 72 h after the treatment, and migration within all layers of the retina was seen at day 7 when photoreceptor cells were lost. At 21, 35 and 150 days after the treatment, lack of photoreceptor cells and deposition of pigment epithelial cells within the retina but not in contact to vascular endothelial cells were characteristic. MNU-induced photoreceptor apo...Continue Reading
References
Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Feb 1, 1972·The American Journal of Anatomy·D W CaleyR A Liebelt
Nov 1, 1967·Archives of Ophthalmology·K M Herrold
Dec 1, 1982·Ophthalmology·S Gartner, P Henkind
Nov 1, 1980·The Journal of Comparative Neurology·S SanyalR K Hawkins
May 1, 1995·Ophthalmology·Z Y LiA H Milam
Jan 1, 1993·Toxicologic Pathology·H OginoR Montesano
Citations
Jul 23, 1999·Survey of Ophthalmology·N N OsborneM S Nash
Oct 20, 1998·Progress in Retinal and Eye Research·C E ReméA Wenzel
Sep 16, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Hua XuYa-Dong Huang
Jun 1, 1997·Pathology International·H NambuA Tsubura
May 20, 1998·Pathology International·H NambuA Tsubura
Jul 25, 2000·The British Journal of Ophthalmology·F HafeziC E Remé
Jul 12, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yuko EmotoAiro Tsubura
Apr 16, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Miriam ReisenhoferVolker Enzmann
Mar 1, 2012·Journal of Pharmacological Sciences·Kazuhiro TsurumaHideaki Hara
Aug 30, 2005·Neurotoxicology·Terry J MillerMartin A Philbert
May 20, 2016·PloS One·Juan WangGuo-Tong Xu
Dec 22, 2015·Scientific Reports·Ye TaoYi Fei Huang
Feb 19, 2009·Journal of Neuroscience Research·Kohei HommaMasayo Takahashi
Oct 14, 2009·The European Journal of Neuroscience·Domitille L BoudardDavid Hicks
Mar 3, 2020·Frontiers in Pharmacology·Chong LiYe Tao
Sep 5, 2020·Pharmaceutics·Karine BigotFrancine Behar-Cohen
Feb 1, 2020·Scientific Reports·Kaori Nomura-KomoikeHiroki Fujieda
Jul 18, 2003·Current Eye Research·Katsuji KiuchiAiro Tsubura