PMID: 22558481May 5, 2012Paper

Pigmented adenoid cystic carcinoma of the ear skin arising from the epidermis: a case report with immunohistochemical studies.

International Journal of Clinical and Experimental Pathology
Tadashi Terada

Abstract

Adenoid cystic carcinoma (ACC) in the skin is very rare; only about 60 cases have been reported. Herein presented is a case of pigmented ACC arising from epidermis of the ear skin. An 85-year-old man presented black tumor of the right ear. Dermatologists' diagnosis was basal cell carcinoma (BCC). Large biopsy was obtained. The biopsy showed proliferation of atypical basaloid cells arranged in a cribriform pattern. The tumor cells were continuous with epidermis, as if it arose from the epidermis. Focal areas show melanin deposition in the tumor cells. Mucin stains showed that the tumor cells and tubular lumens contained acidic mucin. Immunohistochemically, the tumor cells were positive for cytokeratin (CK) AE1/3, CK34BE12, CK5/6, CK7, CK14, p63, alpha-smooth muscle actin (ASMA), S100 protein, p53, Ki-67 (labeling 85%), KIT, PDGFRA and CD56. The tumor cells were negative for CK CAM5.2, CK8, CK18, CK19, CK20, EMA, desmin, CEA, HMB45, CD10, CD34, neuron-specific enolase, chromogranin, synaptophysin, CDX2, MUC1, MUC2, MUC5AC and MUC6. HMB-positive and S100-positive melanocytes were seen in a very few areas. Since characteristic cribriform pattern was recognized in the tumor and the tumor showed epithelial markers, myoepithelial mark...Continue Reading

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Related Papers

International Journal of Clinical and Experimental Pathology
Tadashi Terada
International Journal of Clinical and Experimental Pathology
Tadashi Terada
Applied Immunohistochemistry & Molecular Morphology : AIMM
Tadashi Terada
© 2021 Meta ULC. All rights reserved