Pigmented Epithelioid Melanocytoma (Animal Types of Melanoma) on the Nose

Case Reports in Oncology
Kentaro OhuchiSetsuya Aiba

Abstract

Pigmented epithelioid melanocytoma (PEM), also known as an animal-type melanoma, is a distinctive group of melanocytic tumors with a more favorable prognosis than conventional melanoma. Since tumor-associated macrophages (TAMs) extend in the premetastatic lymph nodes in several cancers, we hypothesized that the lower rate of lymph node metastasis in PEM might be correlated with the phenotypes of TAMs. Therefore, in this report, we further investigate the subpopulation of TAMs in PEM, revealing that the main population of TAMs in histiocytic lesion is CD163+CD206+PD-L1+ M2-polarized macrophages. In addition, since the PD-L1-expressing CD205+ dendritic cells are also detected in histiocytic lesions, the PD-L1-expressing TAMs and dendritic cells might suggest favorable prognostic factors in patients with PEM.

References

Sep 24, 2009·The American Journal of Surgical Pathology·Rajni V MandalArtur Zembowicz
Nov 21, 2012·Acta Dermato-venereologica·Anna SadayasuSetsuya Aiba
May 8, 2014·The Journal of Dermatology·Yasuhiro FujisawaManabu Fujimoto
Oct 16, 2014·Cancer Immunology, Immunotherapy : CII·Maria A Clavijo-SalomonJose Alexandre M Barbuto
Nov 29, 2015·The British Journal of Dermatology·E MoscarellaG Ferrara
Jun 14, 2016·Journal of Dermatological Science·Taku FujimuraSetsuya Aiba
Nov 25, 2016·The Journal of Dermatology·Dai OgataTetsuya Tsuchida
Apr 19, 2017·Journal of the American Academy of Dermatology·Michael J BaxGlynis A Scott
Feb 8, 2018·Frontiers in Oncology·Taku FujimuraSetsuya Aiba
Feb 14, 2018·The Journal of Experimental Medicine·Curtis J PerrySusan M Kaech

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BETA
biopsy

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