Pigmented pleomorphic adenoma, a novel melanin-pigmented benign salivary gland tumor

Virchows Archiv : an International Journal of Pathology
Yasunori TakedaS Nakamura

Abstract

This paper reports a pleomorphic adenoma with grossly visible pigmentation resulting in the macroscopic appearance of melanotic lesion in a 33-year-old Japanese male. In addition to the characteristic histopathological features of a benign pleomorphic adenoma, variously formed and -sized cells, many of which were considered to be melanocytes, containing melanin pigment in their cytoplasm, were distributed in the epithelial component. In addition, melanin pigment was deposited in tumor cells of duct structures. Furthermore, condensed secretory substances with marked pigmentation were frequently seen in the tubular lumina. Perusal of the English language literature revealed only two cases of parenchymal pigmentation of salivary gland tumors: both were mucoepidermoid carcinoma. The possible histogenesis of melanocytes in the salivary gland lesions is discussed, though no firm conclusion could be drawn.

Citations

Jan 24, 2006·Virchows Archiv : an International Journal of Pathology·Saral S Desai, Anita M Borges
Mar 10, 2005·Virchows Archiv : an International Journal of Pathology·Joji SekineTsugio Inokuchi
Jun 12, 2009·Journal of Cutaneous Pathology·Bob N BernabaDavid S Cassarino
Apr 12, 2011·Histopathology·Jag Bhawan
Aug 9, 2005·International Journal of Surgical Pathology·Gianluca MarucciMaria P Foschini
Feb 17, 2021·Head and Neck Pathology·Costantino RicciMaria Pia Foschini

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