Pigmented Porokeratosis. A Further Variant?

The American Journal of Dermatopathology
Tracy S P Tan, Ben Tallon

Abstract

Porokeratosis is a clonal disorder of keratinization characterized by the presence of the cornoid lamella. A number of variants of porokeratosis have been described, based on the clinical features and histologic features of the lesions. The authors present a case of porokeratosis with prominent melanocytic hyperplasia, which was biopsied to clinically exclude melanoma. The authors retrospectively studied cases of porokeratosis to look for the presence of melanocytic hyperplasia. Melanocytic hyperplasia was identified in 8 of 31 cases (25.8%). All of the cases except the index case were clinically nonpigmented but arose in solar damaged skin. This case represents a distinct variant of porokeratosis, and the authors propose the designation pigmented porokeratosis. Melanocytic hyperplasia is a benign condition, and it is important that this is not histologically confused with melanoma in situ, particularly in a context of clinically pigmented lesion. Increased recognition of pigmented porokeratosis is essential to avoid an erroneous diagnosis of melanoma in situ.

References

Jan 1, 1980·The American Journal of Dermatopathology·T R Wade, A B Ackerman
Sep 5, 2002·The British Journal of Dermatology·C-S ShenK Yamanishi
Sep 25, 2007·The American Journal of Dermatopathology·Elizabeth K Satter
Jul 11, 2009·The American Journal of Dermatopathology·Joelle MalekSamer Ghosn
Oct 1, 2010·The American Journal of Dermatopathology·Ben Tallon, Lorenzo Cerroni
Feb 21, 2014·JAMA Dermatology·Ashley C ParksCheryl A Armstrong

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Citations

Mar 8, 2017·The American Journal of Dermatopathology·Ben Tallon, Patrick Emanuel
Sep 20, 2017·Journal of Cutaneous Medicine and Surgery·Bahman SotoodianThomas G Salopek
Jul 13, 2018·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Giovanni PaolinoPietro Donati
Feb 13, 2021·Journal of Cosmetic Dermatology·Irving Llibrán Reyna-RodríguezJorge Ocampo-Candiani
Dec 22, 2020·Indian Dermatology Online Journal·Sankha KoleySupratim Saha

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