Pigmented variant of pleomorphic xanthoastrocytoma - A rare long-term epilepsy associated neoplasm

Indian Journal of Pathology & Microbiology
Rajalakshmi PoyuranAnita Mahadevan

Abstract

Pleomorphic xanthoastrocytoma (PXA) is an uncommon, long-term epilepsy associated tumor of young adults. Its pigmented variant is exceedingly rare, with only five previously reported cases on record. We report the sixth case of pigmented PXA in a 24-year-old lady presenting with long-standing seizures. The MRI revealed a solid cystic lesion located in the right medial temporal lobe. Histopathologically, the superficially located tumor showed typical features of PXA with melanin-laden astrocytic component and was negative for V600E-mutant BRAF. The histogenesis is discussed.

Citations

Jun 20, 2020·Journal of Cellular Physiology·Soha AbdelwahabSara Mohamed Naguib Abdel-Hafez
Aug 11, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Rajalakshmi PoyuranSusarla Krishna Shankar

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