Pigmented villonodular synovitis. A rare differential diagnosis of synovial joint swelling

Zeitschrift für Rheumatologie
K A JendrissekR Janka

Abstract

Pigmented villonodular synovitis (PVNS) describes a rare disease caused by an abnormal proliferation of the synovial membrane in large and small joints. In order to achieve an optimal result of treatment it is necessary to carry out specific diagnostics and a targeted therapy approach. This article gives a review of the epidemiology, etiopathogenesis and diagnostic management of PVNS as well as presenting the current therapy and treatment recommendations. A systematic search of the literature was performed in the databank of the National Center for Biotechnology Information ( http://www.ncbi.nlm.nih.gov/pubmed ). The search targeted randomized clinical and experimental studies, systematic and non-systematic review articles, expert opinions and case reports related to PVNS, independent of the level of evidence attained by each study. The differential diagnosis of PVNS should be considered in cases of recurrent hemorrhagic joint effusions. The cause of the disease has not yet been exactly clarified. The final diagnosis can ultimately only be confirmed by histological investigations. In order to obtain representative histological tissue samples for the diagnosis, magnetic resonance imaging (MRI) with the appropriate heme sequences...Continue Reading

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Citations

Jun 25, 2020·MMW Fortschritte der Medizin·Alexander ZimmererWolfgang Miehlke
Sep 9, 2017·Revista Brasileira De Ortopedia·Eduardo Frois TemponiLúcio Honório de Carvalho Júnior
Sep 8, 2018·Zeitschrift für Rheumatologie·H BastianE Feist
Apr 9, 2021·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·Peter HunoldUNKNOWN Vorstand der Gesellschaft für Pädiatrische Radiologie e. V. (GPR):

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