Pigmented villonodular synovitis therapy with MSCF-1 inhibitors

Current Opinion in Oncology
H Thomas Temple

Abstract

Giant cell tumor of tendon sheath and pigmented villonodular synovitis are synovial-based diseases that are generally treated by surgery. For aggressive and recurrent tumors, treatment alternatives are needed. This review explores a targeted therapeutic strategy. Imatinib, a tyrosine kinase inhibitor, blocks expression of colony stimulating factor 1 (CSF1) by a small subpopulation of tumor cells that recruit CSF1-bearing nonneoplastic cells. Limited clinical data support the efficacy and side effect profile of imatinib in stabilizing disease in most patients. Imatinib along with other such inhibitors and monoclonal antibodies to CSF1R are putative drugs that may play an important role in the treatment of these tumors.

References

Sep 1, 1984·Annals of Plastic Surgery·R C Savage, E B Mustafa
Apr 1, 1993·Genes, Chromosomes & Cancer·F MertensF Mitelman
Jun 15, 1995·International Journal of Radiation Oncology, Biology, Physics·B O'SullivanR Goldberg
Apr 1, 1994·Human Pathology·C G RowlandsR J Sevick
Aug 1, 1996·Cancer Genetics and Cytogenetics·Y OhjimiM Kikuchi
Jun 12, 1998·Journal of Surgical Oncology·C RodriguesR Chinoy
Oct 3, 2002·The Journal of Bone and Joint Surgery. British Volume·C L M H GibbonsN A Athanasou
Nov 26, 2002·Virchows Archiv : an International Journal of Pathology·M NilssonN Mandahl
Jan 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Robert B WestMatt van de Rijn
Feb 21, 2006·Journal of the American Academy of Dermatology·Jong Woong Park
Oct 6, 2007·Genes, Chromosomes & Cancer·Emely MöllerIoannis Panagopoulos
Feb 26, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-Y BlayI Ray-Coquard
Jun 23, 2009·Clinical Orthopaedics and Related Research·Vivek Sharma, Edward Y Cheng
Feb 2, 2010·International Journal of Radiation Oncology, Biology, Physics·Kathryn Beal, Beryl McCormick
May 22, 2010·International Journal of Radiation Oncology, Biology, Physics·Reinhard HeydUNKNOWN German Cooperative Group on Radiotherapy for Benign Diseases
Oct 5, 2010·Seminars in Arthritis and Rheumatism·Sébastien OttavianiLaure Gossec
Apr 1, 2011·Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deut·R D LargoA R Jandali
May 18, 2011·Current Opinion in Oncology·Vinod RaviValerae O Lewis

❮ Previous
Next ❯

Citations

Jan 16, 2016·Zeitschrift für Rheumatologie·K A JendrissekR Janka
Jan 18, 2017·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Akshay D BahetiSree Harsha Tirumani
Jan 19, 2018·Pediatric Rheumatology Online Journal·Mohsen KaramiReza Shiari
Oct 1, 2019·Anti-cancer Drugs·Sara Elena RebuzziDanila Comandini
May 1, 2020·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Yasuyuki Kitagawa, Shinro Takai
Jul 25, 2018·Acta ortopedica brasileira·Tiago Lazzaretti FernandesArnaldo José Hernandez
Mar 23, 2021·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Tun Hing Lui
Aug 9, 2021·Drug Delivery and Translational Research·Anujan RameshAshish A Kulkarni

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.