Pigs are not a reliable experimental model in the study of the haemodynamic and respiratory effects of CO2 pneumoperitoneum

Acta Anaesthesiologica Scandinavica
L RichardJ Fusciardi

Abstract

Haemodynamic and respiratory effects of a CO2 pneumoperitoneum (intra-abdominal pressure = 12 mmHg) associated to a head-up position(15 degrees ) were studied in 20 pigs using a Swan-Ganz catheter and the Single Breath Test for CO2. The pneumoperitoneum induced a moderate rise in mean arterial pressure (+17%) (P<0.001) without any variation in heart rate, cardiac output and systemic vascular resistances. The following respiratory effects were observed: an increase in PaCO2 (+20%) (P<0.001), PE'CO2 (+31%) (P<0.001), expired volume of CO2 (+28%) (P<0.001), arterial to end-tidal CO2 gradient (+80%) (P<0.001) and alveolar dead space (+40%) (P<0.001) occured. Alveolar ventilation remained stable. Finally and contrary to healthy human patient, intraperitoneal CO2 insufflation in pig induced slight haemodynamic changes and major respiratory modifications. Thus, our data do not support the conclusion that the pig is a reliable experimental model for studying the pathophysiology of CO2 pneumoperitoneum-induced changes in haemodynamic and respiratory parameters, in human patients.

References

Sep 1, 1991·Gastroenterology·J A Solis-HerruzoA Gozalo
Jul 1, 1981·British Journal of Anaesthesia·B M Wright
May 1, 1996·Acta Anaesthesiologica Scandinavica·E BuresL Lacoste
Jan 10, 1998·British Journal of Anaesthesia·J E Bazin, P Schoeffler
Aug 12, 2000·Acta Anaesthesiologica Scandinavica·A M Koivusalo, L Lindgren

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Citations

Jul 14, 2010·British Journal of Anaesthesia·D ForsS Rubertsson
Jan 25, 2006·Acta Anaesthesiologica Scandinavica·U JerseniusD Arvidsson
Jun 14, 2003·Acta Anaesthesiologica Scandinavica·C A GreimJ Schulte am Esch
Mar 18, 2004·Acta Anaesthesiologica Scandinavica·K MyreO Stokland

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