Abstract
EGFR is frequently overexpressed in cervical cancer, suggesting EGFR blockade as a promising treatment approach. Cetuximab, an anti EGFR antibody, used conjointly with radiochemotherapy, was feasible in first-line treatment of cervix carcinoma limited to the pelvis. This randomized phase II trial enrolled 78 FIGO stage IB2-IIIB cervical cancer patients to either cisplatin-based radiochemotherapy alone (arm B, n = 38) or conjointly with a 6-week course of weekly cetuximab (arm A, n = 40). Brachytherapy was given to the pelvic mass. Primary endpoint was disease-free survival (DFS) at 2 years. EGFR expression and targeted sequencing were performed in 54 of 78 patients. Cetuximab over a 6-week period did not improve DFS at 24 months. At 31 months median follow-up, DFS was not significantly different (P = 0.18). Complete response at 4 to 6 months was strongly predictive for excellent DFS (log-rank test; P < 0.001). PIK3CA, KRAS, and STK11 mutations were observed in 22%, 4%, and 2% of patients, respectively. No tumor with a PI3K pathway mutation showed complete response (0/8 in arm A and 0/6 in arm B), whereas 14 of 52 (27%) tumors without mutations did (P = 0.021). PI3K pathway-mutated tumors showed a trend toward poorer DFS (P = 0....Continue Reading
References
Apr 15, 1999·The New England Journal of Medicine·P G RoseS Insalaco
Jun 28, 2003·International Journal of Radiation Oncology, Biology, Physics·David K GaffneyMark Dodson
Sep 15, 2005·Gynecologic Oncology·Christopher M LeeDavid K Gaffney
Oct 24, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H Arias-PulidoC F Verschraegen
Aug 2, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F PerroneS Pilotti
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Nov 10, 2009·The Lancet Oncology·James A BonnerK Kian Ang
Nov 19, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maartje G NoordhuisAte G J van der Zee
Sep 23, 2010·American Journal of Clinical Oncology·José Pérez-RegaderaEduardo Lanzós
Oct 15, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J B Vermorken, P Specenier
Mar 23, 2011·Lung·Ezzeldin M IbrahimGhieth A Kazkaz
Jun 10, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ingeborg TinhoferUlrich Keilholz
Jul 20, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E-H TanK M Hui
Jul 27, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Qing ZhouYi-Long Wu
Aug 13, 2011·Oral Oncology·Shiang-Fu HuangLing-Ling Hsieh
Nov 8, 2011·The Lancet Oncology·Robert PirkerKenneth J O'Byrne
Jan 12, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Julie K SchwarzPerry W Grigsby
Feb 22, 2012·International Journal of Radiation Oncology, Biology, Physics·Tracey E SchefterDavid K Gaffney
Mar 24, 2012·International Journal of Clinical Oncology·Satoshi FujiiAtsushi Ochiai
Sep 11, 2012·Gynecologic Oncology·Kathleen N MoorePaula M Fracasso
Dec 26, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lisa LicitraFortunato Ciardiello
Jul 4, 2013·Targeted Oncology·M Di BartolomeoUNKNOWN Italian Trials in Medical Oncology Group
Sep 17, 2013·Cancer·Alexi A WrightMichelle S Hirsch
Sep 17, 2013·Journal of Surgical Oncology·Xiaoli ZhuXingming Chen
Sep 26, 2013·Cancer Research·Jeonghee ChoMatthew Meyerson
Dec 18, 2013·International Journal of Radiation Oncology, Biology, Physics·Tracey SchefterUNKNOWN Radiation Therapy Oncology Group (RTOG)
Dec 18, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jean-Louis PujolNick Thatcher
Mar 29, 2014·Nature·Chong SunRene Bernards
Aug 27, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K Kian AngRita S Axelrod
Citations
Feb 22, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I TinhoferUNKNOWN DKTK-ROG
Feb 3, 2016·Virchows Archiv : an International Journal of Pathology·Diána BrauswetterIstván Peták
Dec 3, 2015·Current Opinion in Obstetrics & Gynecology·Alfonso Dueñas-González, Sergio Campbell
Sep 12, 2015·Scientific Reports·Libing XiangHuijuan Yang
Jul 22, 2015·PloS One·Vivian M SpaansEkaterina S Jordanova
Feb 28, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ebubekir DiricanAyşe Özer
May 25, 2016·British Journal of Cancer·Wulfran CacheuxAstrid Lièvre
Nov 5, 2015·BMC Cancer·Charlotte NgoUNKNOWN RAIDs consortium http://www.raids-fp7.eu/
Dec 7, 2016·British Journal of Cancer·Christopher M JonesDuncan C Gilbert
Nov 3, 2016·Therapeutic Advances in Gastroenterology·Marina De RosaPaolo Delrio
Mar 27, 2016·Oncotarget·Eric DeutschJean-Charles Soria
Nov 17, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Satoru SagaeUNKNOWN Gynecologic Cancer InterGroup Cervix Cancer brainstorming day
May 31, 2017·Cancer Medicine·Robert F KoncarNooshin Hashemi Sadraei
Nov 21, 2019·Journal of the National Cancer Institute·Brian T BeatyBhishamjit S Chera
Nov 1, 2020·Scientific Reports·Takafumi WatanabeKeiya Fujimori
May 16, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cyrus ChargariEric Deutsch
Jun 18, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hong LouMichael Dean
Sep 22, 2020·Gynecologic Oncology·Yuya YoshimotoTakashi Nakano
Dec 11, 2020·Leukemia·Montserrat EstruchKim Theilgaard-Mönch
Mar 20, 2021·BMC Cancer·Shahana SharminMahmuda Yasmin
Apr 14, 2019·Gynecologic Oncology·Sandro PignataUNKNOWN MITO Investigators
Jul 13, 2020·Gynecologic Oncology·Kevin MartellCorinne M Doll
Aug 31, 2021·Seminars in Radiation Oncology·Shivani SudColette J Shen
Aug 31, 2021·Seminars in Radiation Oncology·Brian T BeatyAshley A Weiner
Jan 22, 2020·International Journal of Radiation Oncology, Biology, Physics·Laura BourillonCéline Bourgier