Pillar[5]arene-based, dual pH and enzyme responsive supramolecular vesicles for targeted antibiotic delivery against intracellular MRSA.

Chemical Communications : Chem Comm
Haibo PengYun He

Abstract

A rationally designed mannosylated amphiphilic pillar[5]arene (Man@AP5) self-assembles into supramolecular vesicles with encapsulated vancomycin (Man@AP5-Van), which target macrophages, respond to both acid and cathepsin B, and release vancomycin (Van) rapidly inside macrophages. Man@AP5-Van significantly increases the intracellular concentration of Van, enhancing its antibacterial efficacy against intracellular MRSA.

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Citations

Nov 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dmitriy N ShurpikPeter J Cragg
Dec 8, 2020·European Journal of Medicinal Chemistry·Yujie GaoQiang Peng
Sep 1, 2021·Advanced Drug Delivery Reviews·Santhni SubramaniamClive A Prestidge
Oct 27, 2021·Chemical Communications : Chem Comm·Lisa J WhiteJennifer R Hiscock

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Methods Mentioned

BETA
NMR
dynamic
transmission electron microscopy

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