Pilomatrix carcinoma with multiple visceral metastases. Report of a case

H P NiedermeyerH Höfler


The malignant variant of pilomatrixoma is pilomatrix carcinoma, a low-grade, malignant lesion with a tendency to recur. Only three cases with visceral metastases, occurring some years after primary diagnosis, have been reported. A case of metastatic pilomatrix carcinoma of the neck in a patient, age 50 years, is presented. Histologic examination of the cutaneous lesion showed a dense infiltrate of basaloid cells, an abrupt transition to shadow cells, and central necrosis. Two months after primary diagnosis, pulmonary and brain metastases developed. Despite chemotherapy and irradiation, the patient died a widespread disease 18 months after the primary diagnosis. An autopsy confirmed the diagnosis of pilomatrix carcinoma with metastases to several organs including the heart, lung, brain, liver, pancreas, kidney, adrenal gland, gastric and colorectal submucosa, skin, and bone. Pilomatrix carcinoma is very rare and usually behaves like a low-grade, malignant lesion with a tendency to recur. This patient's tumor is unique because of its highly aggressive behavior and visceral metastases.


Aug 1, 1992·The British Journal of Dermatology·R J Hills, F A Ive
Jun 1, 1992·Journal of Cutaneous Pathology·J B SloanC Jaworsky
Apr 1, 1992·The American Journal of Dermatopathology·A J MarrogiL P Dehner
Sep 1, 1988·The Journal of Investigative Dermatology·I MollR Moll
Dec 1, 1988·The American Journal of Dermatopathology·F G AloiM Pippione
Sep 1, 1988·International Journal of Dermatology·A TaaffeH P Bury
Sep 1, 1987·The British Journal of Dermatology·T HashimotoR Harada
Feb 1, 1987·The American Journal of Dermatopathology·M Jacobson, A B Ackerman
Aug 1, 1987·Journal of the American Academy of Dermatology·D E GreenM R Fowler
Oct 1, 1987·The American Journal of Dermatopathology·P E LeBoitS H Choy
Oct 1, 1986·Journal of Surgical Oncology·K T Chen, D R Taylor
Oct 1, 1973·Archives of Dermatology·F W Moehlenbeck
Jul 1, 1984·Pediatric Dermatology·R SchlechterF M Guttman
Jul 1, 1982·Journal of the American Academy of Dermatology·R A SwerlickS E Mackel
Sep 1, 1981·International Journal of Dermatology·E Hernández-Pérez, R F Cestoni-Parducci
Feb 1, 1980·Journal of Cutaneous Pathology·D WeedonJ Mayze
Oct 1, 1993·Histopathology·D G O'DonovanD E Markham
Oct 1, 1994·International Journal of Dermatology·S KadduS Hödl
Apr 1, 1961·Archives of Dermatology·R FORBIS, E B HELWIG

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