Pilot-controlled trial of the extracorporeal liver assist device in acute liver failure

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
A J EllisR Williams

Abstract

The objective of this pilot controlled study was to evaluate the extracorporeal liver assist device (ELAD) in patients with acute liver failure who were judged to still have a significant chance of survival (approximately 50%) and in those who had already fulfilled criteria for transplantation. Twenty-four patients were divided into two groups, 17 with a potentially recoverable lesion (group I) and 7 listed for transplantation (group II), and then randomly allocated to ELAD haemoperfusion or control. The median period of ELAD haemoperfusion was 72 hours (range 3-168 h). Biocompatibility of the device was good, with no acceleration in platelet consumption, and haemodynamic stability was maintained. Two patients were withdrawn from the study because of worsening of preexisting disseminated intravascular coagulation in one case and a hypersensitivity reaction in the other. Deterioration with respect to encephalopathy grade was more frequent in the control patients, 7 of 12 (58%), than in the ELAD-treated patients, 3 of 12 (25%). In group I where survival for the ELAD cases was 7 of 9 (78%), there was a higher than expected survival in the controls, 6 of 8 (75%). For group II cases, survival was 1 of 3 (33%) for the ELAD-treated pa...Continue Reading

Citations

Dec 1, 1996·Cell Biology and Toxicology·B FrémondB Clément
Mar 1, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Martin SauerJan Stange
Sep 12, 2000·Current Gastroenterology Reports·P Rosenthal
Jan 18, 2003·Current Gastroenterology Reports·Javier Vaquero, Andres T Blei
Jan 27, 2009·Current Gastroenterology Reports·Norman L SussmanJames H Kelly
Feb 9, 2013·Current Gastroenterology Reports·Rafael BañaresJavier Vaquero
Nov 30, 2005·Current Treatment Options in Gastroenterology·Jelica KurtovicRoger Williams
Sep 25, 2002·Transplantation Proceedings·A G R Sheil
Aug 5, 2009·Nature Reviews. Gastroenterology & Hepatology·R Todd Stravitz, David J Kramer
May 18, 2000·Artificial Organs·P D HayJ D Gaylor
Apr 5, 2000·Annals of Surgery·H B StockmannJ N IJzermans
Jul 27, 2004·Annals of Surgery·Maarten Paul van de KerkhoveThomas M van Gulik
Apr 6, 2012·Current Opinion in Organ Transplantation·Jason A WertheimAlejandro Soto-Gutierrez
May 13, 2004·Gut·R JalanR Williams
Mar 8, 2005·Postgraduate Medical Journal·J G O'Grady
May 15, 2013·BMC Gastroenterology·Ahmed Al-ChalabiBernhard Kreymann
Jul 1, 2008·Regenerative Medicine·Jörg C GerlachJohn F Patzer Ii
Jan 17, 2013·World Journal of Gastroenterology : WJG·Marco CarboneJames Neuberger
Oct 31, 2001·Lancet·P C Hayes, A Lee
Oct 30, 2013·Nature Reviews. Gastroenterology & Hepatology·Benjamin StrueckerIgor M Sauer
Jul 6, 2014·Seminars in Pediatric Surgery·Joseph P Vacanti, Katherine M Kulig
May 9, 2014·Annals of Biomedical Engineering·Debanti SenguptaSong Li
Jun 10, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Norman L Sussman, James H Kelly
Dec 2, 2014·Clinics in Liver Disease·Rafael BañaresJavier Vaquero
May 26, 2004·Transplant Immunology·Clare Selden, Humphrey Hodgson
May 26, 2004·Transplant Immunology·Katherine M Kulig, Joseph P Vacanti
Dec 7, 2002·Seminars in Cell & Developmental Biology·Jared W Allen, Sangeeta N Bhatia
Oct 9, 2003·Wiener klinische Wochenschrift·Robin D Hughes
Nov 9, 2006·Indian Journal of Pediatrics·Sanjay Bansal, Anil Dhawan
Jun 28, 2015·Advanced Drug Delivery Reviews·Nathanael RaschzokIgor M Sauer
Jun 2, 2012·Expert Opinion on Biological Therapy·Geert A A NibourgRuurdtje Hoekstra
Nov 15, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Xavier Wittebole, Philippe Hantson
Oct 4, 2005·Current Medical Research and Opinion·S SougioultzisJ N Plevris
Jul 23, 1999·Annals of the New York Academy of Sciences·B Busse, J C Gerlach
Dec 13, 2012·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Xiao-Ping Pan, Lan-Juan Li
Jun 8, 2012·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Li-Fu ZhaoLan-Juan Li
Jun 7, 2011·Gastroenterología y hepatología·Pau Sancho-Bru
Sep 28, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Maurizio Muraca

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.