Pilot epidemiologic study of transmission of cytomegalovirus from mother to preterm infant by breastfeeding

Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
S Croly-LabourdetteJ Sizun

Abstract

Transmission of cytomegalovirus (CMV) infection from mothers to preterm infants during breastfeeding may be symptomatic and long term consequences are unknown. This study evaluated the kinetics of CMV load in breastmilk and the rate of postnatal CMV transmission via breastmilk from mothers to their preterm infants. Prospective study of mother-child pairs after preterm delivery before 33 weeks. Exclusion of donor breast milk and of CMV-seropositive blood products. Material used was maternal CMV serostatus, ear swab of the infant at birth, weekly screened breast milk and children's urine by rapid viral culture. During a 5-month period 28 mother-infant pairs with 34 preterm infants were studied. Eighteen women (64.3%) were CMV-seronegative at birth; breastmilk samples and the infants' urine remained CMV-negative. Eight of the 10 seropositive mothers, who had 11 preterm infants, excreted CMV into breast milk (80%). CMV excretion into breast milk was detected during the first week after delivery in 66% cases and was at its peaked between 3 to 5 weeks after delivery. Out of the 7 CMV-exposed infants, CMV transmission was confirmed in only one asymptomatic case. Total quantity of breast milk intake did not seem discriminative for CMV ...Continue Reading

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Citations

Oct 21, 2011·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Ho-Torng HsuZorina Khalid
Dec 31, 2009·Obstetrical & Gynecological Survey·Laura E Baecher-LindAllen J Wilcox
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Aug 23, 2019·Journal of Clinical Immunology·Brieanne A DergousoffNicola A M Wright
Mar 31, 2021·Journal of Korean Medical Science·Hye Won ParkKyo Sun Kim
May 29, 2013·Pediatrics·Tatiana M LanzieriStephanie R Bialek

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