Pilot experience with opebacan/rBPI 21 in myeloablative hematopoietic cell transplantation

F1000Research
Eva C GuinanOfer Levy

Abstract

Bacterial infection and inflammation contribute significantly to the morbidity and mortality of myeloablative allogeneic hematopoietic cell transplantation (HCT). Endotoxin, a component of the outer membrane of Gram-negative bacteria, is a potent inflammatory stimulus in humans. Bactericidal/permeability increasing protein (BPI), a constituent of human neutrophil granules, binds endotoxin thereby precluding endotoxin-induced inflammation and also has direct anti-infective properties against bacteria. As a consequence of myeloablative therapy used in preparation for hematopoietic cell infusion, patients experience gastrointestinal leak of bacteria and bacterial toxins into the systemic circulation and a period of inflammatory cytokine elevation associated with subsequent regimen-related toxicities.  Patients frequently become endotoxemic and febrile as well as BPI-deficient due to sustained neutropenia. To examine whether enhancing endotoxin-neutralizing and anti-infective activity by exogenous administration of a recombinant N-terminal fragment of BPI (rBPI 21, generic name opebacan) might ameliorate regimen-related toxicities including infection, we recruited patients scheduled to undergo myeloablative HCT to participate in a ...Continue Reading

References

Apr 1, 1995·The Journal of Clinical Investigation·H JinJ B Baker
Jul 1, 1994·Annals of Surgery·M A RogyS F Lowry
Jun 1, 1996·The Journal of Surgical Research·P S DahlbergD L Dunn
Jan 1, 1995·Acta Anatomica·R O'Rahilly
Feb 27, 1999·Current Opinion in Immunology·R J Ulevitch, P S Tobias
Dec 10, 1999·Journal of the American College of Cardiology·C J WiedermannJ Willeit
Feb 4, 2003·Nature Reviews. Immunology·Bruce Beutler, Ernst Th Rietschel
Nov 14, 2003·The Pediatric Infectious Disease Journal·Ofer LevyEva Guinan
Sep 9, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Bruce R Blazar, William J Murphy
Nov 23, 2006·Nature Medicine·Jason M BrenchleyDaniel C Douek
Oct 6, 2007·Immunologic Research·Theresa L Gioannini, Jerrold P Weiss
Dec 19, 2007·Infection and Immunity·Robert S Munford
Feb 8, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Cheuk-Chun SzetoPhilip Kam-Tao Li
Nov 23, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Marco M DominguesNuno C Santos

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Citations

Sep 29, 2018·Nature Reviews. Gastroenterology & Hepatology·Niv ZmoraEran Elinav
Jan 10, 2019·Nature Reviews. Genetics·Alex H Nishida, Howard Ochman

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Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT00454155

Software Mentioned

R

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